{"id":"W2928827501","doi":"10.1016/j.cbi.2019.03.019","title":"Eosinophil peroxidase oxidizes isoniazid to form the active metabolite against M. tuberculosis, isoniazid-NAD+","year":2019,"lang":"en","type":"article","venue":"Chemico-Biological Interactions","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Cancer Foundation","keywords":"Isoniazid; NAD+ kinase; Chemistry; Eosinophil peroxidase; Metabolite; Peroxidase; Biochemistry; Enzyme; Superoxide dismutase; Tuberculosis; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002517927,0.0005891577,0.0007120604,0.0001732564,0.0005612472,0.00008487132,0.0007577633,0.00041066,0.003921517],"category_scores_gemma":[0.0002594095,0.0003657689,0.0004505885,0.0004534445,0.0002993847,0.0003575291,0.0004758449,0.00118116,0.009274918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00021574,"about_ca_system_score_gemma":0.00005813603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006193008,"about_ca_topic_score_gemma":0.00002072308,"domain_scores_codex":[0.9971704,0.0002754923,0.0005991683,0.0009536219,0.00008978543,0.0009115065],"domain_scores_gemma":[0.9979947,0.0006523232,0.0002244085,0.0007454884,0.0002491526,0.0001339598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003386995,0.0003265536,0.0002754428,0.000009002737,0.0003708533,0.000005682904,0.0004922352,0.000006041209,0.987941,0.001788202,0.003814961,0.00463137],"study_design_scores_gemma":[0.0006844485,0.0002863932,0.002157565,0.00004559028,0.00007008202,0.00006572447,0.001092391,0.000005363211,0.7932599,0.0004395116,0.2014547,0.0004383352],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850756,0.0008093576,0.0001223397,0.004303946,0.001679758,0.0009962165,0.0002421023,0.0002276914,0.006542974],"genre_scores_gemma":[0.9867715,0.0003098974,0.0001837411,0.005943385,0.0001956773,0.0003299418,0.0004135436,0.00004431691,0.005807973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1976398,"threshold_uncertainty_score":0.9998794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01878096810284191,"score_gpt":0.26092510672049,"score_spread":0.2421441386176481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}