{"id":"W2928945526","doi":"10.1016/j.neuropharm.2019.03.033","title":"Positive allosteric modulation of the type 1 cannabinoid receptor reduces the signs and symptoms of Huntington's disease in the R6/2 mouse model","year":2019,"lang":"en","type":"article","venue":"Neuropharmacology","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Allison University; University of Saskatchewan; Dalhousie University","funders":"National Eye Institute; National Institute on Drug Abuse; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Endocannabinoid system; Allosteric modulator; Cannabinoid receptor; Allosteric regulation; Agonist; Cannabinoid; Striatum; Huntington's disease; Pharmacology; Receptor; Genetically modified mouse; Neuroscience; Biology; Chemistry; Internal medicine; Medicine; Transgene; Disease; Biochemistry; Gene; Dopamine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001118326,0.000141401,0.0001522077,0.00005397006,0.00008748697,0.00001500347,0.0005004077,0.00002733617,0.00003367706],"category_scores_gemma":[0.0003301506,0.00007935751,0.00005363041,0.0003272347,0.0003414887,0.00006859322,0.0001852502,0.0001674088,0.000005735236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000117604,"about_ca_system_score_gemma":0.000101243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000141287,"about_ca_topic_score_gemma":0.000001562021,"domain_scores_codex":[0.9979312,0.001049707,0.0002335686,0.0003488062,0.000242347,0.0001943285],"domain_scores_gemma":[0.9989718,0.0004008752,0.0001978202,0.0003068508,0.0000781721,0.00004448176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001848431,0.0001045931,0.004343606,0.00001568447,0.000003383794,7.158511e-7,0.0005070216,0.02640506,0.9680375,0.0001525484,0.0001096701,0.0001353844],"study_design_scores_gemma":[0.0003687489,0.000248621,0.06030829,0.000005548396,0.0000361331,8.552585e-7,0.00003174019,0.01575558,0.9230865,0.00004974702,0.00003043459,0.00007778932],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969862,0.00002830003,0.000002164944,0.001627963,0.0003486416,0.0008299337,0.00007404842,0.000008699471,0.0000940811],"genre_scores_gemma":[0.9970213,0.00003407944,0.000005267755,0.002595506,0.00002695135,0.00002868533,0.000001482589,0.00001859799,0.0002681044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05596469,"threshold_uncertainty_score":0.3236105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01813644683607641,"score_gpt":0.2716350972186026,"score_spread":0.2534986503825262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}