{"id":"W2929065785","doi":"10.3390/cells8040304","title":"3D Telomere Structure Analysis to Detect Genomic Instability and Cytogenetic Evolution in Myelodysplastic Syndromes","year":2019,"lang":"en","type":"article","venue":"Cells","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Genome instability; Telomere; Myelodysplastic syndromes; Biology; Evolutionary biology; Computational biology; Genetics; DNA; Bone marrow; DNA damage; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002063882,0.00015786,0.0001149931,0.0007347185,0.0000978758,0.0002519389,0.0000866875,0.0002028761,0.0006498502],"category_scores_gemma":[0.0003100676,0.000084085,0.0001444724,0.0002897048,0.0001175135,0.0001283428,0.0002167893,0.000216294,0.0001198318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001424316,"about_ca_system_score_gemma":0.00006751128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003816701,"about_ca_topic_score_gemma":0.0007384198,"domain_scores_codex":[0.9999181,0.00002429652,0.000008417772,0.00001390039,0.00002437694,0.00001075693],"domain_scores_gemma":[0.9998735,0.00002679394,0.00004252027,0.00001466368,0.00002538512,0.00001705504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003741052,0.00001948125,0.03460054,0.00005328195,0.00002733132,0.0002399856,0.0001288215,0.0004457425,0.9509396,0.0001363275,0.00007299496,0.01296187],"study_design_scores_gemma":[0.00003349823,0.0006108573,0.6178862,0.00002814615,0.00009692636,0.004754661,0.0002536658,0.01363457,0.3583679,0.0005105549,0.003790037,0.0000330351],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994356,0.001075206,0.003904136,0.00002988232,0.000006983151,0.000009339678,0.0001718099,0.00002475848,0.0004218731],"genre_scores_gemma":[0.9954882,0.000315072,0.003656678,0.00001789792,0.000004252313,0.00001169341,0.0001909999,0.000004878454,0.0003103499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007347185,"threshold_uncertainty_score":0.002173901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008802282306175238,"score_gpt":0.2539109191726162,"score_spread":0.245108636866441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}