{"id":"W2930092902","doi":"10.1016/j.mrgentox.2019.03.005","title":"Role of aneuploidy in the carcinogenic process: Part 3 of the report of the 2017 IWGT workgroup on assessing the risk of aneugens for carcinogenesis and hereditary diseases","year":2019,"lang":"en","type":"review","venue":"Mutation Research/Genetic Toxicology and Environmental Mutagenesis","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Canada","funders":"","keywords":"Aneuploidy; Carcinogenesis; Biology; Cancer; Carcinogen; Cancer research; Chromosome instability; Genetics; Chromosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007663679,0.000226629,0.0005481648,0.00007773231,0.0001911352,0.00001066784,0.0005022227,0.0002497649,0.000006700212],"category_scores_gemma":[0.0003311849,0.0001214992,0.000275176,0.0001784244,0.001033679,0.000004352116,0.0002776802,0.0001872271,2.017712e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004426939,"about_ca_system_score_gemma":0.0003162059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008978981,"about_ca_topic_score_gemma":0.00009855181,"domain_scores_codex":[0.9975562,0.0008065929,0.0006385423,0.0004207594,0.0003374038,0.0002405054],"domain_scores_gemma":[0.997622,0.0008229575,0.0007131674,0.0007618971,0.00004074035,0.00003926772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000657649,0.00196603,0.4722279,0.01918837,0.002056252,0.00005484783,0.002796787,0.008366199,0.05857906,0.00007959428,0.000699129,0.4333282],"study_design_scores_gemma":[0.001149979,0.001541897,0.9328196,0.001234157,0.002800392,0.0003054157,0.004649638,0.0001736521,0.0315995,0.000411054,0.02283448,0.0004802455],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5840919,0.4141361,0.00000266394,0.00002859889,0.00006482667,0.001073962,0.0005890468,4.606846e-7,0.00001242593],"genre_scores_gemma":[0.62379,0.3758465,0.00001424064,0.00001714789,0.00004956653,0.0001757064,0.00006777027,0.00001892874,0.00002006007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4605917,"threshold_uncertainty_score":0.4954595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03599824266643156,"score_gpt":0.3361106865675868,"score_spread":0.3001124439011553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}