{"id":"W2930186558","doi":"10.1128/jvi.00304-19","title":"Effects of the SOS (A501C/T605C) and DS (I201C/A433C) Disulfide Bonds on HIV-1 Membrane Envelope Glycoprotein Conformation and Function","year":2019,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; National Institute of General Medical Sciences; Canada Research Chairs","keywords":"Glycoprotein; Biology; Cysteine; Viral envelope; Disulfide bond; Membrane protein; Cell biology; Protein structure; Virus; Envelope (radar); Viral entry; Native state; Human immunodeficiency virus (HIV); Function (biology); Biophysics; Biochemistry; Membrane; Virology; Viral replication","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002278911,0.0002259806,0.0001391064,0.00009521141,0.0001349059,0.0001981946,0.0001321474,0.0002674614,0.001171161],"category_scores_gemma":[0.0002784594,0.0000940454,0.0001870203,0.00009343016,0.0002251992,0.0001579357,0.0001048742,0.0003055953,0.0001290739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001518923,"about_ca_system_score_gemma":0.000142156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008975843,"about_ca_topic_score_gemma":0.0008105808,"domain_scores_codex":[0.9998715,0.00004648317,0.00001301558,0.00001493382,0.00001873026,0.00003535909],"domain_scores_gemma":[0.9998407,0.00004832239,0.00003411562,0.00001143991,0.0000162774,0.00004902853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003593817,0.0004812366,0.001176367,0.00005733276,0.0000478734,0.0001876339,0.00004520881,0.0004839443,0.9896594,0.0001872417,0.0001085612,0.003971344],"study_design_scores_gemma":[0.0001461667,0.007019601,0.01123565,0.00001768728,0.00007403909,0.0003689984,0.00009457361,0.001687946,0.9779633,0.00009778669,0.001278261,0.00001595444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995079,0.0002037223,0.0000302652,0.00001291757,0.000007978195,0.000002546368,0.00002522682,0.000002524476,0.0002068263],"genre_scores_gemma":[0.9993643,0.0002042067,0.00008250626,0.00002759652,0.000003745034,0.000002353922,0.000057806,0.000003686069,0.0002538719],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001171161,"threshold_uncertainty_score":0.003917933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003871047065247324,"score_gpt":0.2057159592293208,"score_spread":0.2018449121640735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}