{"id":"W2930191041","doi":"10.3389/fimmu.2019.00699","title":"N-Linked Glycosylation Regulates CD22 Organization and Function","year":2019,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; The Scarborough Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"CD22; breakpoint cluster region; Glycosylation; Sialic acid; Cell biology; Glycan; Receptor; SIGLEC; B-cell receptor; Biology; Signal transduction; B cell; Chemistry; Glycoprotein; Biochemistry; Antibody; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000085212,0.0002066085,0.0001199307,0.00008736876,0.0001602815,0.0003999324,0.0001460594,0.000268304,0.001042734],"category_scores_gemma":[0.0001317538,0.000100766,0.0001733133,0.0001010147,0.0002026132,0.0001863688,0.0001908032,0.0005228748,0.0003346246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003319935,"about_ca_system_score_gemma":0.0001488374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008867722,"about_ca_topic_score_gemma":0.0009234801,"domain_scores_codex":[0.9998583,0.00001921011,0.000008799862,0.00002697526,0.0000404,0.00004628805],"domain_scores_gemma":[0.9998837,0.00001262496,0.00003388914,0.00001084092,0.00001924808,0.00003977489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004894517,0.00001184685,0.0003006863,0.000011958,0.000001711412,0.00004114418,0.000009708855,0.00005379324,0.9987445,0.00009503248,0.00003562607,0.0006450807],"study_design_scores_gemma":[0.000009871491,0.00007718099,0.01935499,0.000007457485,0.00001463734,0.0003571298,0.00007096834,0.002123963,0.9731616,0.000132778,0.004681039,0.000008478449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967819,0.0008468759,0.001138588,0.00009506434,0.00001588268,0.000006403354,0.00008967319,0.00002876196,0.0009967438],"genre_scores_gemma":[0.9972018,0.000431273,0.0009143453,0.00006038012,0.000004762889,0.00000879713,0.0001312295,0.0000163965,0.001230964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001042734,"threshold_uncertainty_score":0.003488243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004266227928502463,"score_gpt":0.2097779294684139,"score_spread":0.2055117015399115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}