{"id":"W2930461140","doi":"10.1097/coh.0000000000000541","title":"Clinical and evolutionary consequences of HIV adaptation to HLA","year":2019,"lang":"en","type":"review","venue":"Current Opinion in HIV and AIDS","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; Simon Fraser University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Human leukocyte antigen; Adaptation (eye); Immunogen; Human immunodeficiency virus (HIV); Population; Epitope; Immunology; HIV vaccine; Biology; Medicine; Virology; Antigen; Antibody; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004803854,0.0006294322,0.0009707387,0.0009408721,0.0001880372,0.000892505,0.0006567173,0.0009117103,0.003610499],"category_scores_gemma":[0.00100971,0.0001652888,0.0003002715,0.001039681,0.0003491772,0.0009609368,0.0005285897,0.001461231,0.001840081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004799851,"about_ca_system_score_gemma":0.00108883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005909244,"about_ca_topic_score_gemma":0.0007332357,"domain_scores_codex":[0.999848,0.0000372847,0.0000223834,0.00002577734,0.00004904385,0.00001746254],"domain_scores_gemma":[0.9996845,0.0001638582,0.00004645497,0.000007577754,0.00007073952,0.00002680717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000815281,0.00002781815,0.0001993399,0.0160558,0.00006692301,0.0002174416,0.00005948783,0.0002889399,0.001043055,0.00355847,0.05562846,0.9227726],"study_design_scores_gemma":[0.00001397882,0.00007727495,0.001018696,0.005103492,0.00009103357,0.001747878,0.00008239176,0.0000874801,0.0003103312,0.00223612,0.9892144,0.00001691433],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008008413,0.9981453,0.00008781792,0.0004656513,0.0004946348,0.00000465886,0.00001356348,0.000004850152,0.0007034337],"genre_scores_gemma":[0.0004639468,0.9982911,0.0000918912,0.0003198295,0.0003859305,0.000005864439,0.00002270395,0.000001161241,0.0004177036],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003610499,"threshold_uncertainty_score":0.01207829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1876646656475954,"score_gpt":0.441174061196859,"score_spread":0.2535093955492635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}