{"id":"W2930562129","doi":"10.3390/cells8040291","title":"Cellular and Animal Models of Striated Muscle Laminopathies","year":2019,"lang":"en","type":"review","venue":"Cells","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"LMNA; Lamin; Nuclear lamina; Emerin; Biology; Genetics; Phenotype; Exon; Cardiac muscle; Skeletal muscle; RNA splicing; Gene isoform; Mutation; Gene; Penetrance; Progeria; Cell biology; Nuclear protein; Anatomy; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006281022,0.0001793537,0.0004808781,0.00003992522,0.00001757816,0.0000100679,0.00009646963,0.0003379818,0.00001643341],"category_scores_gemma":[0.000004980187,0.0001483984,0.0001461318,0.00004933135,0.00004154272,0.000001999706,0.0000859,0.00009541407,0.00001180189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004511005,"about_ca_system_score_gemma":0.00004982817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004883443,"about_ca_topic_score_gemma":5.761347e-7,"domain_scores_codex":[0.9993004,0.00004550191,0.0002093174,0.0002708843,0.00006162103,0.0001122628],"domain_scores_gemma":[0.9995042,0.000007583533,0.0001543067,0.0002722913,0.00003079486,0.00003079619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003355689,0.00003570415,0.000001040039,0.01224688,0.0002035511,0.000004191358,0.00003745269,0.000009656365,0.2081626,0.0001942446,0.001565303,0.7775058],"study_design_scores_gemma":[0.0001241022,0.0002078267,0.000001882579,0.000378964,0.0002636519,0.000003902611,0.000009208588,0.00001748367,0.006631684,0.00002069799,0.9921624,0.0001781942],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003224665,0.9953026,0.00006740806,8.15749e-7,0.0002101212,0.0002295945,0.00005704306,0.000005127453,0.0009025849],"genre_scores_gemma":[0.003581621,0.9953025,0.0001044115,0.000007964462,0.000139619,0.000003077599,0.0001971988,0.00003269316,0.0006309339],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9905971,"threshold_uncertainty_score":0.6051509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02780998447303066,"score_gpt":0.2485784855835015,"score_spread":0.2207685011104709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}