{"id":"W2930562129","doi":"10.3390/cells8040291","title":"Cellular and Animal Models of Striated Muscle Laminopathies","year":2019,"lang":"en","type":"review","venue":"Cells","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"LMNA; Lamin; Nuclear lamina; Emerin; Biology; Genetics; Phenotype; Exon; Cardiac muscle; Skeletal muscle; RNA splicing; Gene isoform; Mutation; Gene; Penetrance; Progeria; Cell biology; Nuclear protein; Anatomy; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003878623,0.0007722541,0.001037629,0.001991356,0.0002409266,0.0006598731,0.0008154883,0.0008833888,0.003888959],"category_scores_gemma":[0.0003359549,0.0002026959,0.0004223499,0.001029079,0.0003283766,0.0006550027,0.0005686843,0.001286604,0.00250188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004105455,"about_ca_system_score_gemma":0.0005266512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005809266,"about_ca_topic_score_gemma":0.001241618,"domain_scores_codex":[0.9998631,0.00001974155,0.00001915187,0.00002661432,0.0000567933,0.00001458976],"domain_scores_gemma":[0.9998829,0.00004932504,0.0000172899,0.000005990383,0.00002923889,0.00001520944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001419174,0.0001317328,0.0002342637,0.02291785,0.0001346036,0.0006158705,0.00008034345,0.0004340854,0.01709146,0.00838209,0.03752675,0.912309],"study_design_scores_gemma":[0.00001626308,0.00008579761,0.0004946995,0.002088401,0.00010386,0.00168741,0.00002968702,0.00005514957,0.001840032,0.001617152,0.9919667,0.00001488358],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000449719,0.9944881,0.0004632229,0.0002173612,0.0002496035,0.00001724588,0.0001044405,0.00002564786,0.003984808],"genre_scores_gemma":[0.001465169,0.9960925,0.0004525693,0.000201349,0.00007525743,0.00001883743,0.0001678875,0.000004050867,0.001522279],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003888959,"threshold_uncertainty_score":0.01300991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02780998447303066,"score_gpt":0.2485784855835015,"score_spread":0.2207685011104709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}