{"id":"W2930654133","doi":"10.1073/pnas.1816023116","title":"Hepatic posttranscriptional network comprised of CCR4–NOT deadenylase and FGF21 maintains systemic metabolic homeostasis","year":2019,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Shriners Hospitals for Children - Canada; McGill University; McGill University Health Centre","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Ministry of Education, Culture, Sports, Science and Technology; National Institute on Aging; Svenska Forskningsrådet Formas; National Institute on Alcohol Abuse and Alcoholism; Terry Fox Research Institute; Howard Hughes Medical Institute; Vetenskapsrådet; Government of Canada; Canadian Institutes of Health Research; University of Texas System; Fonds de Recherche du Québec - Santé","keywords":"FGF21; Regulator; Biology; Energy homeostasis; Adipose tissue; Paracrine signalling; Homeostasis; Hormone; Cell biology; Endocrinology; Fibroblast growth factor; Biochemistry; Receptor; Obesity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009739934,0.0000977115,0.0001917385,0.0001031844,0.00008228033,0.00001444336,0.0005215101,0.00009770992,0.00001289639],"category_scores_gemma":[0.0001974826,0.00007108844,0.00008177589,0.0003775919,0.0006409328,0.0000251282,0.0001667315,0.0001119058,0.0000010896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001089053,"about_ca_system_score_gemma":0.00005913811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000629353,"about_ca_topic_score_gemma":1.037506e-7,"domain_scores_codex":[0.9983861,0.00001850507,0.0003093012,0.0002493121,0.0008515542,0.0001851631],"domain_scores_gemma":[0.99931,0.00005971258,0.0002734462,0.00001505669,0.0002977501,0.00004403597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006154801,0.0000217291,0.05038587,0.0001836187,0.00003597538,3.062452e-9,0.00004157965,0.0001563704,0.9387942,0.01012573,0.0001138034,0.00007957305],"study_design_scores_gemma":[0.0003619009,0.0001449024,0.2456588,0.0001448328,0.00001563442,0.00001692166,0.0001076271,0.0004884378,0.7509253,0.001918794,0.0001254908,0.00009129658],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979242,0.0008875923,0.000003116211,0.0005380374,0.00001692687,0.0002661889,0.00005957754,0.000002734614,0.0003016455],"genre_scores_gemma":[0.9989486,0.0001396471,0.0006828474,0.00009307295,0.00005642063,0.000006362498,0.000001029258,0.000005707808,0.00006634779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.195273,"threshold_uncertainty_score":0.2898903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02663527774179927,"score_gpt":0.2891597086492819,"score_spread":0.2625244309074827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}