{"id":"W2930688952","doi":"10.1002/jcsm.12405","title":"Early myopathy in Duchenne muscular dystrophy is associated with elevated mitochondrial H<sub>2</sub>O<sub>2</sub> emission during impaired oxidative phosphorylation","year":2019,"lang":"en","type":"article","venue":"Journal of Cachexia Sarcopenia and Muscle","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":134,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; McMaster University; York University","funders":"","keywords":"Duchenne muscular dystrophy; Oxidative phosphorylation; Bioenergetics; Myopathy; Mitochondrial myopathy; Mitochondrion; Dystrophin; Wasting; Mitochondrial disease; Internal medicine; Muscle weakness; Mitochondrial DNA; Endocrinology; Biology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000285263,0.0005158953,0.0003702208,0.000563042,0.0002238375,0.0002974515,0.0001602264,0.0005038691,0.00120495],"category_scores_gemma":[0.0001142581,0.0003174758,0.0002291922,0.0002091771,0.0003062259,0.00018344,0.0002275205,0.0004571313,0.0001594769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002924159,"about_ca_system_score_gemma":0.0001489698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009139656,"about_ca_topic_score_gemma":0.002739767,"domain_scores_codex":[0.9997957,0.0000384141,0.00002522797,0.00005244905,0.00005085141,0.00003729],"domain_scores_gemma":[0.9997831,0.00002807614,0.00007767257,0.00001743221,0.00002425995,0.00006937317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001732722,0.00003124946,0.0009635412,0.0000365802,0.000005617277,0.00007681588,0.0000145895,0.00002125811,0.9983639,0.000008364213,0.000011961,0.0002928832],"study_design_scores_gemma":[0.00003809357,0.002022333,0.1186444,0.00002741015,0.00005935733,0.0007970536,0.0001324815,0.000309178,0.8769896,0.00003579017,0.0009345838,0.00000968641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970399,0.0008328152,0.001032296,0.00003379077,0.00001305885,0.00004813402,0.0002794561,0.00004049365,0.0006800676],"genre_scores_gemma":[0.9948871,0.0006681307,0.00181952,0.00006165062,0.000005995274,0.00006341266,0.0003478895,0.00001173034,0.002134612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00120495,"threshold_uncertainty_score":0.004030943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003987394312608056,"score_gpt":0.1961164022315749,"score_spread":0.1921290079189669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}