{"id":"W2930758931","doi":"10.1016/j.antiviral.2019.03.014","title":"Identification of a clinical compound losmapimod that blocks Lassa virus entry","year":2019,"lang":"en","type":"article","venue":"Antiviral Research","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China; Public Health Agency; Public Health Agency of Canada","keywords":"Lassa virus; Lassa fever; Virology; Arenavirus; Biology; Virus; Immunology; Antigen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.004538894,0.0001223647,0.0004638135,0.0004326634,0.0001275314,0.00006593692,0.000224854,0.0002090048,0.000383444],"category_scores_gemma":[0.0006635918,0.0001001123,0.0002414023,0.0007316675,0.0004374427,0.0001872828,0.0002374546,0.001080172,0.001861897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006523186,"about_ca_system_score_gemma":0.0003338217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005106512,"about_ca_topic_score_gemma":0.00004725374,"domain_scores_codex":[0.9964975,0.0004877703,0.000641267,0.0004482366,0.001382224,0.0005430583],"domain_scores_gemma":[0.9977105,0.0007511346,0.0001139893,0.000629705,0.0006680375,0.000126612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008006433,0.00111417,0.4652134,0.0002089309,0.0001385693,0.00005579908,0.00008404801,6.622244e-7,0.499519,0.0007739219,0.008548392,0.02354255],"study_design_scores_gemma":[0.003461884,0.001905662,0.4455838,0.0002465252,0.00004034405,0.00004152933,0.0004500216,0.003579956,0.5306581,0.0007095042,0.01310362,0.0002190855],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.96344,0.0001385636,0.00006294471,0.0006458925,0.0002298995,0.0007457024,0.00001953062,0.00003150538,0.03468595],"genre_scores_gemma":[0.9737262,0.0005418864,0.00004322901,0.00004406893,0.00021116,0.00001868676,0.00001904699,0.00002332719,0.02537243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03113912,"threshold_uncertainty_score":0.9989153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1868226214171019,"score_gpt":0.5032365179607636,"score_spread":0.3164138965436617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}