{"id":"W2930777517","doi":"10.1038/s41598-019-41839-1","title":"Metformin induces the AP-1 transcription factor network in normal dermal fibroblasts","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; University of Saskatchewan","funders":"Division of Chemistry; Natural Sciences and Engineering Research Council of Canada; Prostate Cancer Canada; Saskatchewan Cancer Agency; University of Saskatchewan","keywords":"Metformin; Transcriptome; Chromatin immunoprecipitation; Biology; Transcription factor; Chromatin; Gene; Genome; Activator (genetics); Gene expression; Cell biology; Endocrinology; Genetics; Internal medicine; Promoter; Diabetes mellitus; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001031081,0.0001844899,0.0001477525,0.0002469139,0.0001802222,0.000254507,0.0001060069,0.0001272087,0.001344223],"category_scores_gemma":[0.00009958396,0.0001355733,0.000214391,0.0001660363,0.0001431018,0.0001035652,0.0001542757,0.0004424202,0.0003511759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002343768,"about_ca_system_score_gemma":0.000226309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001404679,"about_ca_topic_score_gemma":0.001879783,"domain_scores_codex":[0.999849,0.00001847687,0.0000135911,0.00004656083,0.00004292977,0.00002950048],"domain_scores_gemma":[0.9999192,0.00001650371,0.00001576402,0.00001376427,0.00001232767,0.00002256818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009522682,0.00001846945,0.0001649158,0.00001784653,0.000003099895,0.00003152132,0.00001042149,0.00003476955,0.9987771,0.00003324023,0.00003524878,0.0007780641],"study_design_scores_gemma":[0.00001905783,0.0002097624,0.01312913,0.000005254611,0.00001356472,0.0001489968,0.00005683532,0.0008785689,0.9822457,0.00006441514,0.003224325,0.000004277023],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912552,0.001587174,0.003229705,0.0001415621,0.00006323325,0.00004424381,0.001273726,0.00008569856,0.002319489],"genre_scores_gemma":[0.9920021,0.000868139,0.002303591,0.0001068131,0.00001123245,0.00006860003,0.001156587,0.00002292007,0.00346007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001404679,"threshold_uncertainty_score":0.004496932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009096476701606935,"score_gpt":0.2247638459072638,"score_spread":0.2156673692056569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}