{"id":"W2930821061","doi":"10.1016/j.str.2019.03.008","title":"Altered Domain Structure of the Prion Protein Caused by Cu2+ Binding and Functionally Relevant Mutations: Analysis by Cross-Linking, MS/MS, and NMR","year":2019,"lang":"en","type":"article","venue":"Structure","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institutes of Health","keywords":"Gene isoform; Prion protein; Chemistry; Plasma protein binding; Residue (chemistry); Biophysics; Nuclear magnetic resonance spectroscopy; Amino acid; Biochemistry; Intramolecular force; Peptide sequence; Amino acid residue; Molecular dynamics; Protein structure; Biology; Stereochemistry; Gene; Computational chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007708184,0.000180113,0.0001894555,0.0000505497,0.0001636916,0.00006998556,0.0001479814,0.0002041468,0.0001302021],"category_scores_gemma":[0.00004472516,0.0001317152,0.00009182953,0.0002001484,0.000111788,0.00001106328,0.0001207269,0.0001428303,2.984457e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001453302,"about_ca_system_score_gemma":0.0000536537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002926073,"about_ca_topic_score_gemma":0.00004995328,"domain_scores_codex":[0.9989228,0.00007662964,0.0002267939,0.0004014782,0.0001962605,0.000176082],"domain_scores_gemma":[0.9993177,0.00001168744,0.0002142067,0.0003171734,0.00007142429,0.00006778164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005785873,0.000005335339,0.04605128,0.0000685519,0.0002384918,2.17524e-7,0.00005783328,0.0001026054,0.9521531,0.00006264366,0.0002370592,0.0009650422],"study_design_scores_gemma":[0.002068906,0.0002279514,0.1144729,0.0001022537,0.0003670623,0.00001457942,0.0001335828,0.0002286736,0.8588902,0.004475752,0.01845905,0.0005590617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928085,0.005236141,0.0001789806,0.0001098981,0.00007183883,0.0004750574,0.001100282,0.00000713084,0.00001213748],"genre_scores_gemma":[0.9982497,0.0001506629,0.0004547854,0.00008796454,0.00006512341,0.000006230604,0.0007704225,0.0000172348,0.0001979031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09326286,"threshold_uncertainty_score":0.5371192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002945243881046817,"score_gpt":0.2271782775752727,"score_spread":0.2242330336942259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}