{"id":"W2930821061","doi":"10.1016/j.str.2019.03.008","title":"Altered Domain Structure of the Prion Protein Caused by Cu2+ Binding and Functionally Relevant Mutations: Analysis by Cross-Linking, MS/MS, and NMR","year":2019,"lang":"en","type":"article","venue":"Structure","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institutes of Health","keywords":"Gene isoform; Prion protein; Chemistry; Plasma protein binding; Residue (chemistry); Biophysics; Nuclear magnetic resonance spectroscopy; Amino acid; Biochemistry; Intramolecular force; Peptide sequence; Amino acid residue; Molecular dynamics; Protein structure; Biology; Stereochemistry; Gene; Computational chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000102226,0.0003172462,0.0001624151,0.0002568957,0.0001944021,0.0001415522,0.0001881968,0.0003047867,0.0004965804],"category_scores_gemma":[0.0001676553,0.0001041752,0.0001536577,0.0001749335,0.0002458538,0.0001325195,0.0001100904,0.0003086763,0.0001279862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001824245,"about_ca_system_score_gemma":0.0001060074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007997254,"about_ca_topic_score_gemma":0.0006292678,"domain_scores_codex":[0.9999471,0.0000135793,0.000006094052,0.00001156154,0.00001166317,0.00001003382],"domain_scores_gemma":[0.9998682,0.00003014752,0.0000420966,0.00001109089,0.00001743604,0.00003108976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001229373,0.00001826827,0.0003410642,0.00001707964,0.000006048796,0.0002761553,0.00001679691,0.00007290868,0.9988015,0.00003794791,0.00002358515,0.0002655704],"study_design_scores_gemma":[0.00002905422,0.0002377265,0.03247187,0.00001049206,0.00005560874,0.003742585,0.00007012201,0.00351883,0.9582992,0.0001748363,0.00137046,0.00001929249],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981401,0.0004312643,0.0008917411,0.00003781455,0.000008258957,0.000005420112,0.0002184661,0.00001603762,0.000250935],"genre_scores_gemma":[0.9977384,0.0002113088,0.001304908,0.00004131837,0.000004474687,0.000006343948,0.000351202,0.000009327366,0.000332699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007997254,"threshold_uncertainty_score":0.001661181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002945243881046817,"score_gpt":0.2271782775752727,"score_spread":0.2242330336942259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}