{"id":"W2930830047","doi":"10.1101/598714","title":"Dendritic spines on GABAergic neurons respond to cholinergic signaling in the <i>Caenorhabditis elegans</i> motor circuit","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"National Center for Research Resources; National Institutes of Health; Vanderbilt University; American Heart Association","keywords":"Dendritic spine; Dendritic filopodia; Biology; Postsynaptic potential; Neuroscience; GABAergic; Actin remodeling of neurons; Postsynaptic density; Cell biology; Actin cytoskeleton; Cholinergic; SPINE (molecular biology); Cytoskeleton; Inhibitory postsynaptic potential; Excitatory postsynaptic potential; Cell; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003640146,0.0002504292,0.0001829773,0.0001783388,0.000238625,0.0002456075,0.0002869895,0.0002125367,0.001043579],"category_scores_gemma":[0.00008162114,0.0001683805,0.0001938871,0.00005772118,0.0001670433,0.0001393817,0.0002997998,0.0003951847,0.0002261858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003993088,"about_ca_system_score_gemma":0.0001858683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003415597,"about_ca_topic_score_gemma":0.005985364,"domain_scores_codex":[0.9999456,0.000001821414,0.000002999457,0.00001439558,0.00001824897,0.00001697949],"domain_scores_gemma":[0.9999188,0.000005866679,0.00001853202,0.000005772541,0.00002397659,0.00002709648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002821525,0.000006172586,0.0007058117,0.00002177883,0.000003081518,0.00006333194,0.00000983248,0.0001373141,0.9979234,0.00007300516,0.00006809881,0.0009599722],"study_design_scores_gemma":[0.00003931443,0.0002102443,0.2281821,0.00004524589,0.00007921673,0.0006679958,0.0001846276,0.01016641,0.7569938,0.0003370265,0.003061373,0.00003266811],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963436,0.0002587228,0.001187467,0.00005491647,0.00001412051,0.00001040351,0.0001942799,0.00008510245,0.001851412],"genre_scores_gemma":[0.996714,0.0001934487,0.001231859,0.00004239554,0.000003692513,0.00001761898,0.0001963216,0.00001855663,0.001582208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003415597,"threshold_uncertainty_score":0.006791413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01356583683546706,"score_gpt":0.219997903560728,"score_spread":0.2064320667252609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}