{"id":"W2930954504","doi":"10.1038/s41418-019-0325-6","title":"MiR-35 buffers apoptosis thresholds in the C. elegans germline by antagonizing both MAPK and core apoptosis pathways","year":2019,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Toronto; SickKids Foundation; National Research Council Canada; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Garron Family Cancer Centre; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Cell biology; Germline; Apoptosis; MAPK/ERK pathway; Programmed cell death; Biology; microRNA; DNA damage; Signal transduction; Genetics; Gene; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001055138,0.0003459562,0.0002097367,0.0002175594,0.000170233,0.0002690845,0.0002399894,0.0002504531,0.0008013723],"category_scores_gemma":[0.0001313442,0.0001908148,0.0001918397,0.00005532745,0.000264747,0.0002255883,0.0002932179,0.0005469447,0.0001912932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000440121,"about_ca_system_score_gemma":0.0003306047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009601297,"about_ca_topic_score_gemma":0.002014911,"domain_scores_codex":[0.9998739,0.00001226482,0.00001409825,0.00003415357,0.00003740155,0.00002816177],"domain_scores_gemma":[0.9998887,0.00001747391,0.00003720317,0.000008713097,0.00001401429,0.00003392311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000410033,0.000007030161,0.00006342823,0.00001642612,0.000001548816,0.00001301385,0.000006211744,0.00004340769,0.9992643,0.00006229497,0.00001796718,0.0004634805],"study_design_scores_gemma":[0.00001148069,0.0001455599,0.002426477,0.00000633891,0.00001308493,0.0000653616,0.00001992014,0.0009985245,0.99415,0.00006572909,0.002090697,0.000006831887],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940048,0.001184798,0.002578397,0.0001147778,0.00003938342,0.00002277508,0.0002359864,0.0001723319,0.001646809],"genre_scores_gemma":[0.9942426,0.0004632888,0.003018883,0.00006936431,0.000005438631,0.00002555462,0.0001676822,0.00003401651,0.001973041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009601297,"threshold_uncertainty_score":0.003193319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01249135130849286,"score_gpt":0.2103740536435469,"score_spread":0.1978827023350541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}