{"id":"W2931260132","doi":"10.1016/j.nbd.2019.04.005","title":"An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2","year":2019,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Dementias Platform UK; Innovative Medicines Initiative; Oxford University Hospitals NHS Foundation Trust; University of Oxford; Parkinson's UK; National Institute for Health and Care Research; Medical Research Council; Stem Cell Network; Hermann und Lilly Schilling-Stiftung für Medizinische Forschung; Wellcome Trust","keywords":"LRRK2; Endocytic cycle; Biology; Rab; Endocytosis; Cell biology; Dopaminergic; Parkinson's disease; Mutation; Neuroscience; Genetics; Pathology; Gene; Disease; Receptor; Medicine; GTPase; Dopamine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001913216,0.0004865389,0.0003821524,0.0004949812,0.0001713712,0.0004224777,0.0001673123,0.0003869136,0.0004929155],"category_scores_gemma":[0.0001193203,0.0001174521,0.0004880285,0.0003642716,0.0001904436,0.0001693248,0.0002280172,0.0003966909,0.0001899058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003427383,"about_ca_system_score_gemma":0.0001945523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005305258,"about_ca_topic_score_gemma":0.0009892974,"domain_scores_codex":[0.9998391,0.000008794257,0.00001323179,0.00004768352,0.00006891145,0.00002229192],"domain_scores_gemma":[0.999911,0.00001503358,0.00003325221,0.000008570911,0.00001897478,0.00001321305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004739428,0.000007612669,0.0007706105,0.00002478552,0.00001353539,0.0001077779,0.000007018713,0.00006646348,0.9983472,0.0000163152,0.00002230577,0.0005690298],"study_design_scores_gemma":[0.00001455995,0.0002247486,0.1008968,0.00001275712,0.0001386667,0.001959101,0.00009107853,0.005509316,0.8893267,0.0001972767,0.001612319,0.00001676775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987532,0.001047304,0.008283431,0.0001264727,0.00002345195,0.0000306304,0.002323862,0.0001436002,0.0004892673],"genre_scores_gemma":[0.981101,0.001177716,0.01263603,0.000192996,0.00001598698,0.00007190645,0.003789306,0.00003755759,0.0009773733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005305258,"threshold_uncertainty_score":0.002486765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005959807716673313,"score_gpt":0.2110867239801224,"score_spread":0.2051269162634491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}