{"id":"W2931338058","doi":"10.1016/j.stem.2019.03.005","title":"Polycomb/Trithorax Antagonism: Cellular Memory in Stem Cell Fate and Function","year":2019,"lang":"en","type":"review","venue":"Cell stem cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; National Institutes of Health; China Scholarship Council","keywords":"Biology; Antagonism; Stem cell; Function (biology); Cell biology; Cell fate determination; Polycomb-group proteins; Neuroscience; Genetics; Transcription factor; Repressor; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008991697,0.001253459,0.001562894,0.001486564,0.0002897161,0.001261669,0.001484911,0.001653668,0.00276772],"category_scores_gemma":[0.0007312072,0.0003194486,0.0002859939,0.002277406,0.0009868926,0.001440452,0.0009565969,0.002460363,0.002367554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001176276,"about_ca_system_score_gemma":0.001010302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001079185,"about_ca_topic_score_gemma":0.002422625,"domain_scores_codex":[0.9998242,0.0000269225,0.00002319075,0.00003818341,0.00006686956,0.00002054042],"domain_scores_gemma":[0.9996674,0.0001500362,0.00004298466,0.00001413734,0.00007573713,0.0000495771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001181788,0.00004169152,0.0001303425,0.008074031,0.0000702964,0.0001865963,0.00003451546,0.0004620327,0.003897605,0.008216589,0.06746203,0.9113061],"study_design_scores_gemma":[0.0000182176,0.00004010505,0.0005210412,0.0009761996,0.00006286622,0.0005304211,0.00003696585,0.0000982325,0.0006867378,0.003505723,0.9935056,0.00001789022],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006261973,0.9978113,0.0002235776,0.0004336797,0.0004641025,0.000002512236,0.00002032123,0.000009137817,0.0009728539],"genre_scores_gemma":[0.0006891168,0.9968898,0.0002592893,0.0003955463,0.0005603757,0.000006373728,0.00004400192,0.000002250913,0.001153293],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00276772,"threshold_uncertainty_score":0.009258926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02762801775217288,"score_gpt":0.2602306312282494,"score_spread":0.2326026134760765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}