{"id":"W2931368040","doi":"10.1038/s41586-019-1076-8","title":"Precise therapeutic gene correction by a simple nuclease-induced double-stranded break","year":2019,"lang":"en","type":"article","venue":"Nature","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Allergy and Infectious Diseases; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Human Genome Research Institute; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Center for Advancing Translational Sciences; University of Massachusetts","keywords":"Biology; Frameshift mutation; Genome editing; Genetics; CRISPR; Cas9; Homology directed repair; Mutation; DNA repair; Gene; Nucleotide excision repair","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005510214,0.0006506829,0.000611769,0.000493232,0.0002734517,0.0006257998,0.0005452192,0.001306996,0.002375966],"category_scores_gemma":[0.0005688746,0.0003983621,0.000554933,0.000244733,0.0006989724,0.0004330132,0.0005923824,0.001483872,0.000878424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004478084,"about_ca_system_score_gemma":0.000538638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002951149,"about_ca_topic_score_gemma":0.0005230687,"domain_scores_codex":[0.9992419,0.00008407127,0.00006774019,0.0002075358,0.0002999156,0.00009871294],"domain_scores_gemma":[0.9996592,0.00008287559,0.0001190437,0.00007336631,0.00002195716,0.00004359377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000916581,0.00002908881,0.00007376562,0.0000574639,0.00001561595,0.0001813791,0.00001753759,0.0003449931,0.9912827,0.002420663,0.0002611933,0.005223859],"study_design_scores_gemma":[0.00002490217,0.0001495585,0.0003150883,0.000006819173,0.00001650143,0.0008288979,0.000007900639,0.001153305,0.9915262,0.0004911905,0.005467717,0.00001185633],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5841987,0.004987387,0.3851483,0.001943327,0.001860948,0.0005635868,0.001374722,0.005541113,0.0143818],"genre_scores_gemma":[0.9450009,0.001236711,0.04542968,0.0002411708,0.00005180992,0.00007992751,0.0003033251,0.0001895898,0.007466872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002375966,"threshold_uncertainty_score":0.007948399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00488285864890066,"score_gpt":0.2791021776137105,"score_spread":0.2742193189648099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}