{"id":"W2931406496","doi":"10.1002/ajmg.a.61105","title":"Safety of switching to Migalastat from enzyme replacement therapy in Fabry disease: Experience from the Phase 3 ATTRACT study","year":2019,"lang":"en","type":"letter","venue":"American Journal of Medical Genetics Part A","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital du Sacré-Cœur de Montréal","funders":"Amicus Therapeutics","keywords":"Fabry disease; Enzyme replacement therapy; Medicine; Pharmacology; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001362875,0.0004088108,0.001435416,0.0002175389,0.00005558259,0.0000397454,0.001340999,0.00019897,0.001324326],"category_scores_gemma":[0.001308617,0.0002614102,0.0003094296,0.0004907563,0.0003977077,0.00004264173,0.0002667645,0.003080827,0.00002010727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002141175,"about_ca_system_score_gemma":0.00138301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001416493,"about_ca_topic_score_gemma":0.00005492,"domain_scores_codex":[0.991012,0.0008984866,0.001604961,0.0005575517,0.005351066,0.0005759809],"domain_scores_gemma":[0.995423,0.00169396,0.0009433255,0.001014293,0.0002759511,0.0006495284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0207114,0.005220054,0.2762667,0.00007560474,0.002125366,0.009160963,0.03335608,0.00007361355,0.001180275,2.400865e-7,0.3461661,0.3056636],"study_design_scores_gemma":[0.02569443,0.02177839,0.1265154,0.003382861,0.0004938188,0.00007718084,0.01945394,0.0005725306,0.0002787829,0.00002642051,0.8008997,0.0008264908],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7925454,0.003553221,0.001018833,0.2013497,0.0004200748,0.0009971673,0.00009677849,0.000005231712,0.0000135388],"genre_scores_gemma":[0.8318645,0.003158232,0.0003376587,0.1619179,0.002449621,0.0000421026,0.00007148074,0.00008221657,0.00007633059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4547336,"threshold_uncertainty_score":0.9999838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04135272883008817,"score_gpt":0.3775768799964441,"score_spread":0.3362241511663559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}