{"id":"W2931416517","doi":"10.3390/antib8020027","title":"Single-Domain Antibodies as Therapeutic and Imaging Agents for the Treatment of CNS Diseases","year":2019,"lang":"en","type":"review","venue":"Antibodies","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; National Research Council Canada","funders":"","keywords":"Antibody; Medicine; Cerebrospinal fluid; Single-domain antibody; Central nervous system; Computational biology; Neuroscience; Immunology; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004231934,0.0006901451,0.0007483924,0.002066301,0.000213261,0.0007132113,0.0006015457,0.0009761401,0.003940268],"category_scores_gemma":[0.000416948,0.0001987887,0.0003783797,0.001510455,0.0003900639,0.001000522,0.0004333259,0.001633907,0.002187308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004608011,"about_ca_system_score_gemma":0.000681452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006012156,"about_ca_topic_score_gemma":0.00112808,"domain_scores_codex":[0.9998242,0.00002797845,0.00001746691,0.00002464063,0.0000860428,0.00001955762],"domain_scores_gemma":[0.9998419,0.00007261035,0.00002264154,0.00000487379,0.00004212617,0.00001580628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006652785,0.0001115418,0.0001566042,0.01829015,0.00007071076,0.0002496621,0.00007816427,0.0004491035,0.008687056,0.009948368,0.02549374,0.9363984],"study_design_scores_gemma":[0.000009014278,0.0000824763,0.0003477673,0.001225257,0.00004654221,0.0008019212,0.0000269113,0.00006811167,0.001072347,0.001548876,0.9947613,0.000009441785],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002358893,0.9968485,0.0002207367,0.0001902196,0.0002039831,0.000008051384,0.00001572128,0.00000965793,0.00226715],"genre_scores_gemma":[0.001167888,0.997131,0.000270864,0.0001616612,0.0001381924,0.000008424077,0.00002356284,0.000001424848,0.001096898],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003940268,"threshold_uncertainty_score":0.01318145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1310407975241597,"score_gpt":0.4198972390929485,"score_spread":0.2888564415687888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}