{"id":"W2931416517","doi":"10.3390/antib8020027","title":"Single-Domain Antibodies as Therapeutic and Imaging Agents for the Treatment of CNS Diseases","year":2019,"lang":"en","type":"review","venue":"Antibodies","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; National Research Council Canada","funders":"","keywords":"Antibody; Medicine; Cerebrospinal fluid; Single-domain antibody; Central nervous system; Computational biology; Neuroscience; Immunology; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001380328,0.0006187839,0.002207285,0.0002341421,0.0002797839,0.00006730539,0.0002261668,0.0001230091,0.00007217602],"category_scores_gemma":[0.0000582726,0.0003152617,0.001060175,0.0001513881,0.0006412875,0.00006674178,0.0001086087,0.000149353,0.0000489748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007847992,"about_ca_system_score_gemma":0.000244884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001432099,"about_ca_topic_score_gemma":0.000009327508,"domain_scores_codex":[0.9977918,0.0001130885,0.0006066796,0.000535607,0.0004126631,0.0005401152],"domain_scores_gemma":[0.9973057,0.001564776,0.0002999082,0.0005421058,0.0001496983,0.0001378205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001947292,0.0005044193,0.004597753,0.02275908,0.002136774,0.00004486389,0.0003927099,8.483931e-8,0.00002752797,0.0008525533,0.0008819904,0.9676075],"study_design_scores_gemma":[0.0007011073,0.001017005,0.001193514,0.005343854,0.003986603,0.0001408391,0.0002545985,0.00001819945,0.00003719694,0.0003137862,0.9866848,0.0003084874],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001236209,0.9937834,0.00001412588,0.0006179614,0.0002816683,0.002571607,0.0005375996,0.00003320919,0.0009241906],"genre_scores_gemma":[0.0005697719,0.9896686,0.0001278467,0.0001334882,0.000356224,0.000129696,0.0003066624,0.0000807967,0.008626878],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9858028,"threshold_uncertainty_score":0.99993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1310407975241597,"score_gpt":0.4198972390929485,"score_spread":0.2888564415687888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}