{"id":"W2931486588","doi":"10.1002/ijc.32314","title":"Patterns in metabolite profile are associated with risk of more aggressive prostate cancer: A prospective study of 3,057 matched case–control sets from EPIC","year":2019,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Instituto de Salud Carlos III; World Cancer Research Fund; Medical Research Council; Hellenic Health Foundation; Medical Research Council Canada; Deutsche Krebshilfe; World Health Organization; European Commission; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Cancer Research UK; Deutsches Krebsforschungszentrum; Associazione Italiana per la Ricerca sul Cancro; National Research Council Sri Lanka; Health Research; Centre International de Recherche sur le Cancer","keywords":"Prostate cancer; Metabolite; EPIC; Prospective cohort study; Prostate; Medicine; European Prospective Investigation into Cancer and Nutrition; Oncology; Cancer; Case-control study; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002009638,0.0001509827,0.0004998336,0.0001366985,0.00001510076,0.00001150357,0.0002070762,0.000055574,0.00007212539],"category_scores_gemma":[0.0001218305,0.000110822,0.00009574182,0.0001069144,0.00003360577,0.0000142802,0.00005992262,0.0001673787,2.00767e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008307434,"about_ca_system_score_gemma":0.0001382853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001771428,"about_ca_topic_score_gemma":0.004299914,"domain_scores_codex":[0.9986858,0.000102369,0.0004877936,0.0002042503,0.0003824052,0.000137348],"domain_scores_gemma":[0.996657,0.00004102727,0.002105244,0.0001244705,0.001036192,0.00003612273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001288801,0.000361933,0.9716061,0.00001073708,0.004920646,0.0001493874,0.001133003,0.0007456386,0.01877972,0.000004199527,0.00001417456,0.0009856415],"study_design_scores_gemma":[0.00706854,0.0006256452,0.9600713,0.0002446672,0.0003446241,0.00002446193,0.002306674,0.00007756508,0.02898639,0.0000832324,0.0000334895,0.0001334526],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991854,0.00527638,0.00003235079,0.0001167821,0.0003119344,0.0004543792,0.001930418,0.000001419091,0.00002234789],"genre_scores_gemma":[0.9980036,0.001656383,0.00005963448,0.00003460812,0.0001112941,0.00005557261,0.00001391881,0.00001625441,0.00004874195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01153486,"threshold_uncertainty_score":0.4519189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005028704001799588,"score_gpt":0.2774358181345327,"score_spread":0.2724071141327331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}