{"id":"W2931967123","doi":"10.3389/fmed.2019.00058","title":"Recommendations for Regulating the Environmental Risk of Shedding for Gene Therapy and Oncolytic Viruses in Canada","year":2019,"lang":"en","type":"article","venue":"Frontiers in Medicine","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Simon Fraser University","funders":"Genome Alberta; Alberta Innovates; Alberta Innovates - Health Solutions; Genome Canada","keywords":"Oncolytic virus; Virology; Genetic enhancement; Gene; Biology; Medicine; Genetics; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04130937,0.001718186,0.001287495,0.006763451,0.01421287,0.01776541,0.01047602,0.02479142,0.02779181],"category_scores_gemma":[0.07893317,0.001940154,0.004347946,0.005318629,0.00688666,0.007100878,0.006277274,0.01406951,0.006311965],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.1052377,"about_ca_system_score_gemma":0.5868627,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9652192,"about_ca_topic_score_gemma":0.9764513,"domain_scores_codex":[0.9388753,0.01004444,0.004339388,0.002841089,0.03389252,0.01000724],"domain_scores_gemma":[0.7953943,0.0201207,0.005289481,0.003003987,0.1534222,0.02276932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005113854,0.0001372918,0.001658793,0.001104088,0.00004069312,0.0006214801,0.001570906,0.000998508,0.001465408,0.02170574,0.93549,0.03515591],"study_design_scores_gemma":[0.00005653222,0.0000373621,0.003082679,0.001823343,0.00008155638,0.0001152836,0.00203745,0.0003046184,0.0007036626,0.003964024,0.987628,0.0001655357],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.003061451,0.02445827,0.009110776,0.7538693,0.01455623,0.003658951,0.004745255,0.001399332,0.1851404],"genre_scores_gemma":[0.03783124,0.03790312,0.0832172,0.6428037,0.001822387,0.00302499,0.004252049,0.0005700632,0.1885752],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.8947623,"threshold_uncertainty_score":0.7635562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02225735450731766,"score_gpt":0.2937364833656961,"score_spread":0.2714791288583785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}