{"id":"W2932169608","doi":"10.1111/bjd.17932","title":"The oral Janus kinase/spleen tyrosine kinase inhibitor<scp>ASN</scp>002 demonstrates efficacy and improves associated systemic inflammation in patients with moderate‐to‐severe atopic dermatitis: results from a randomized double‐blind placebo‐controlled study","year":2019,"lang":"en","type":"article","venue":"British Journal of Dermatology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":129,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovaderm (Canada)","funders":"Asana Biosciences","keywords":"Placebo; Eczema Area and Severity Index; Medicine; Atopic dermatitis; Gastroenterology; Internal medicine; Adverse effect; Biomarker; Randomized controlled trial; Systemic inflammation; Pharmacokinetics; Inflammation; Immunology; Pharmacology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007589912,0.0003564282,0.002204903,0.0003077568,0.0002289635,0.0002265162,0.0002268083,0.000294738,0.000005002469],"category_scores_gemma":[0.002564792,0.0002671701,0.00016449,0.000287599,0.0002140986,0.000392846,0.00007925205,0.000609555,0.0000131792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000874065,"about_ca_system_score_gemma":0.00027659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001527192,"about_ca_topic_score_gemma":0.0003342048,"domain_scores_codex":[0.9953132,0.001356053,0.001968205,0.0003793692,0.0004860759,0.000497104],"domain_scores_gemma":[0.9950382,0.002569335,0.001214641,0.0002642475,0.0006324021,0.0002811621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4822978,0.001503033,0.5044115,0.0001279551,0.002156244,0.004313308,0.001491523,0.0001414769,0.0001401249,0.00001567859,0.00188813,0.001513172],"study_design_scores_gemma":[0.685864,0.000337369,0.3062163,0.001233037,0.0006487838,0.003911423,0.0007464208,0.0005209502,0.0002989089,0.00006779724,0.00001448647,0.0001405219],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909032,0.003157512,0.00001710894,0.0006204333,0.0002985474,0.004809703,0.00004737097,0.00003486462,0.0001112754],"genre_scores_gemma":[0.9992405,0.0001794413,0.00007068274,0.000154045,0.00005701142,0.0001105147,0.00009349611,0.00003372862,0.00006056293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2035661,"threshold_uncertainty_score":0.9999781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006940791390641539,"score_gpt":0.2301773568234335,"score_spread":0.2232365654327919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}