{"id":"W2932169608","doi":"10.1111/bjd.17932","title":"The oral Janus kinase/spleen tyrosine kinase inhibitor<scp>ASN</scp>002 demonstrates efficacy and improves associated systemic inflammation in patients with moderate‐to‐severe atopic dermatitis: results from a randomized double‐blind placebo‐controlled study","year":2019,"lang":"en","type":"article","venue":"British Journal of Dermatology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":129,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovaderm (Canada)","funders":"Asana Biosciences","keywords":"Placebo; Eczema Area and Severity Index; Medicine; Atopic dermatitis; Gastroenterology; Internal medicine; Adverse effect; Biomarker; Randomized controlled trial; Systemic inflammation; Pharmacokinetics; Inflammation; Immunology; Pharmacology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001376667,0.0007812894,0.001914985,0.000252703,0.0002723981,0.0005202108,0.0004777765,0.0007477636,0.00290753],"category_scores_gemma":[0.0007910885,0.0003583482,0.0009420001,0.0002728244,0.0008152064,0.0005204803,0.0001866572,0.001213549,0.0004046475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003151066,"about_ca_system_score_gemma":0.0005946355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003915919,"about_ca_topic_score_gemma":0.0009685613,"domain_scores_codex":[0.9995738,0.0002215854,0.00004817147,0.00005787113,0.00005490249,0.00004366081],"domain_scores_gemma":[0.9993574,0.0001924103,0.0001633924,0.00005271388,0.00004430148,0.0001896884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9051905,0.01815454,0.002763571,0.0008358723,0.001023158,0.00008835649,0.00005810082,0.0003013637,0.02717964,0.00006808902,0.0005526568,0.04378404],"study_design_scores_gemma":[0.6738389,0.3074153,0.01372761,0.00003512217,0.0006369789,0.0001562586,0.00003111515,0.0004861958,0.002878676,0.00007615994,0.0006956379,0.00002195526],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960749,0.002202483,0.0002227713,0.000113166,0.00008032734,0.000503646,0.0001824087,0.00003807793,0.0005823088],"genre_scores_gemma":[0.9962574,0.001447074,0.0006072666,0.0002462752,0.0002071584,0.0003644528,0.0003083788,0.000007014898,0.0005550236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00290753,"threshold_uncertainty_score":0.009726703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006940791390641539,"score_gpt":0.2301773568234335,"score_spread":0.2232365654327919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}