{"id":"W2932582301","doi":"10.1155/2019/2015978","title":"Quorum Sensing: A Prospective Therapeutic Target for Bacterial Diseases","year":2019,"lang":"en","type":"review","venue":"BioMed Research International","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":327,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Distinguished Young Scholar Foundation of Hunan Province; China Scholarship Council; National Natural Science Foundation of China; Hunan Agricultural University; National Science Fund for Distinguished Young Scholars; Chinese Academy of Sciences; National Science Foundation","keywords":"Quorum sensing; Autoinducer; Biofilm; Microbiology; Bacteria; Antimicrobial; Homoserine; Virulence; Antibiotic resistance; Antibiotics; Biology; Pathogenic bacteria; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000288664,0.000654058,0.0009200023,0.001742405,0.0002604609,0.0007551814,0.0005599307,0.001084186,0.005274389],"category_scores_gemma":[0.0003266683,0.0001647238,0.0003548089,0.001400208,0.0003404036,0.001151057,0.0006195602,0.001707808,0.002697441],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004180703,"about_ca_system_score_gemma":0.0007059816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003996497,"about_ca_topic_score_gemma":0.0008385042,"domain_scores_codex":[0.9998811,0.00001920693,0.00001197287,0.00002106067,0.00005322694,0.00001335426],"domain_scores_gemma":[0.9998658,0.00004948627,0.00001744792,0.000004488785,0.00004091904,0.00002194947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004868914,0.00007680606,0.0001094293,0.01227311,0.00004556393,0.0002148609,0.00005838641,0.0002183124,0.006217531,0.005842571,0.03741573,0.9374791],"study_design_scores_gemma":[0.00000830738,0.00008439374,0.0003641548,0.001640012,0.00004472382,0.001002468,0.00004775559,0.00007961677,0.0005909787,0.001921078,0.9942052,0.00001123481],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001456541,0.9972976,0.0002399372,0.0004642065,0.0003961454,0.000004758942,0.00001816678,0.00001215113,0.001421439],"genre_scores_gemma":[0.0009619466,0.996955,0.0003015146,0.000273264,0.0002387261,0.000007409138,0.00003179874,0.000002139068,0.001228253],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005274389,"threshold_uncertainty_score":0.01764458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1072007395937844,"score_gpt":0.4219571399376569,"score_spread":0.3147564003438725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}