{"id":"W2932582301","doi":"10.1155/2019/2015978","title":"Quorum Sensing: A Prospective Therapeutic Target for Bacterial Diseases","year":2019,"lang":"en","type":"review","venue":"BioMed Research International","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":327,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Distinguished Young Scholar Foundation of Hunan Province; China Scholarship Council; National Natural Science Foundation of China; Hunan Agricultural University; National Science Fund for Distinguished Young Scholars; Chinese Academy of Sciences; National Science Foundation","keywords":"Quorum sensing; Autoinducer; Biofilm; Microbiology; Bacteria; Antimicrobial; Homoserine; Virulence; Antibiotic resistance; Antibiotics; Biology; Pathogenic bacteria; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005417763,0.0003670012,0.0006725448,0.0003483596,0.0001639294,0.0002373192,0.0005292398,0.0004794602,0.0001069164],"category_scores_gemma":[0.0003629339,0.0002958632,0.0005630981,0.0001969424,0.000227463,0.000008053044,0.0003827254,0.0002707209,0.00008908172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001667476,"about_ca_system_score_gemma":0.0008174402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001167672,"about_ca_topic_score_gemma":0.000004689075,"domain_scores_codex":[0.9973276,0.0002861447,0.0004336692,0.000838651,0.00048159,0.0006323785],"domain_scores_gemma":[0.9984758,0.0001398159,0.0001967,0.0004570538,0.0005771087,0.000153485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006736728,0.0002209515,0.00001162228,0.002861947,0.001616868,0.00001121705,0.00001746698,1.836112e-7,0.07556956,0.0005906295,0.03017177,0.8882541],"study_design_scores_gemma":[0.0005301182,0.0003955044,0.00001001644,0.000786975,0.00009053152,0.00002738115,0.00001058401,0.00001281352,0.001272001,0.00007837612,0.9964452,0.000340454],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001823897,0.985889,0.0001686195,0.0003005729,0.007322431,0.002614498,0.002785704,0.00002865076,0.0007081528],"genre_scores_gemma":[0.0003632757,0.9754549,0.001165065,0.00003999438,0.007882564,0.0001477136,0.009598269,0.0001331109,0.00521513],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9662735,"threshold_uncertainty_score":0.9999493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1072007395937844,"score_gpt":0.4219571399376569,"score_spread":0.3147564003438725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}