{"id":"W2933216334","doi":"10.1096/fasebj.2019.33.1_supplement.528.10","title":"Xanthine Oxidase Mediates Cerebrovascular Function Impairment in Chronically Stressed Mice","year":2019,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Biochemical effects in animals","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institutes of Health","keywords":"Febuxostat; Xanthine oxidase; Xanthine oxidase inhibitor; Oxidative stress; Internal medicine; Medicine; Endocrinology; Xanthine; Endothelial dysfunction; Obesity; Middle cerebral artery; Coronary arteries; Chronic stress; Artery; Uric acid; Chemistry; Hyperuricemia; Ischemia; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002466965,0.0006511546,0.0004468748,0.0005469848,0.0002872857,0.0003696957,0.0003104255,0.0005172379,0.001652965],"category_scores_gemma":[0.0001832748,0.0003883413,0.0005074805,0.0001768785,0.0004085277,0.0002690124,0.0003069317,0.001602274,0.0002959286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002834233,"about_ca_system_score_gemma":0.0002291158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00065361,"about_ca_topic_score_gemma":0.0009477355,"domain_scores_codex":[0.9998066,0.00003003825,0.00001883409,0.00005591401,0.0000308179,0.00005777045],"domain_scores_gemma":[0.9997131,0.00001359783,0.0001182718,0.00002905437,0.00002207534,0.0001038952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001469487,0.0003243895,0.0008989017,0.00005616086,0.00003667256,0.0003762861,0.00006640232,0.00004444695,0.9946853,0.0001416025,0.0001563084,0.001744009],"study_design_scores_gemma":[0.0007893083,0.01252694,0.08958819,0.0001224489,0.0003515877,0.00342959,0.0004440668,0.003365742,0.8848265,0.0006628083,0.003844682,0.00004816529],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971379,0.0007025475,0.001099236,0.0002127468,0.00005593505,0.0000266846,0.0002625498,0.00006110828,0.0004411887],"genre_scores_gemma":[0.9944192,0.00145205,0.001136351,0.0001918508,0.000049832,0.0001283288,0.0006037012,0.00002132727,0.001997359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001652965,"threshold_uncertainty_score":0.005529702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006970738213440623,"score_gpt":0.2394550273660606,"score_spread":0.23248428915262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}