{"id":"W2933305187","doi":"10.1186/s13395-019-0191-4","title":"Late-onset megaconial myopathy in mice lacking group I Paks","year":2019,"lang":"en","type":"article","venue":"Skeletal Muscle","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Common Fund; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Human Genome Research Institute; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; NIH Office of the Director; National Heart, Lung, and Blood Institute; National Institute on Drug Abuse; Natural Sciences and Engineering Research Council of Canada; National Cancer Institute; National Institutes of Health","keywords":"Biology; Myopathy; Muscular dystrophy; Skeletal muscle; Myocyte; Kinase; Cell biology; Knockout mouse; PAK1; Mitochondrion; Actin; Internal medicine; Endocrinology; Pathology; Biochemistry; Medicine; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001457371,0.0001474796,0.0001507514,0.00004451759,0.00004167376,0.00001246048,0.0001773157,0.0001837718,0.0001361282],"category_scores_gemma":[0.00003217798,0.0001498561,0.00009576065,0.000093718,0.00006526282,0.000007719074,0.0001123339,0.0001432267,0.0001647988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009451537,"about_ca_system_score_gemma":0.00003147113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007977065,"about_ca_topic_score_gemma":0.0001897254,"domain_scores_codex":[0.9989896,0.00007667996,0.0001697106,0.0003770425,0.00007351935,0.0003134402],"domain_scores_gemma":[0.9996071,0.00001617394,0.00005044137,0.0002549647,0.00001869999,0.00005256662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001323833,0.0001408854,0.02776392,0.00003948308,0.00002459639,0.000006152825,0.00009904883,0.0001669144,0.9643865,0.0002070286,0.000520968,0.006512119],"study_design_scores_gemma":[0.004714401,0.001283487,0.9084526,0.00005731971,0.00002111622,0.00001141013,0.0004376422,0.0005131539,0.02989681,0.002173981,0.05132553,0.001112518],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945408,0.0003052939,0.00003242135,0.00008703807,0.0003068811,0.0001780669,0.00001171683,0.00001642608,0.004521324],"genre_scores_gemma":[0.99867,0.00004356012,0.00007599738,0.0005662218,0.0001241468,0.00001645111,0.0001417728,0.00002062051,0.0003411881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9344897,"threshold_uncertainty_score":0.6110954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00494528553139187,"score_gpt":0.2256192885199174,"score_spread":0.2206740029885255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}