{"id":"W2933305187","doi":"10.1186/s13395-019-0191-4","title":"Late-onset megaconial myopathy in mice lacking group I Paks","year":2019,"lang":"en","type":"article","venue":"Skeletal Muscle","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Common Fund; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Human Genome Research Institute; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; NIH Office of the Director; National Heart, Lung, and Blood Institute; National Institute on Drug Abuse; Natural Sciences and Engineering Research Council of Canada; National Cancer Institute; National Institutes of Health","keywords":"Biology; Myopathy; Muscular dystrophy; Skeletal muscle; Myocyte; Kinase; Cell biology; Knockout mouse; PAK1; Mitochondrion; Actin; Internal medicine; Endocrinology; Pathology; Biochemistry; Medicine; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002543064,0.001400095,0.000436246,0.001701663,0.0004330177,0.0005275908,0.0004342859,0.001263107,0.005821152],"category_scores_gemma":[0.0002120052,0.0005762546,0.0005553021,0.000454249,0.0006728002,0.0005795609,0.0005297856,0.001450102,0.001586192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004077676,"about_ca_system_score_gemma":0.0003083739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004353294,"about_ca_topic_score_gemma":0.0009195021,"domain_scores_codex":[0.9997482,0.00002489039,0.0000339554,0.00008521437,0.00005888689,0.00004890552],"domain_scores_gemma":[0.999403,0.00004523741,0.0003190808,0.00003023358,0.00003090725,0.00017159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000398821,0.0001482938,0.001279075,0.00009714072,0.00002338003,0.000933026,0.00005106811,0.0001002366,0.9944883,0.0002887356,0.0002563257,0.001935613],"study_design_scores_gemma":[0.0008845911,0.003548201,0.1888711,0.0003687917,0.0003944402,0.02803055,0.00046231,0.004111235,0.7540231,0.0009940007,0.01821523,0.00009654471],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862983,0.001898906,0.004585518,0.0004133394,0.00008462184,0.0001299588,0.003281851,0.0005877128,0.002719725],"genre_scores_gemma":[0.9740366,0.002347833,0.005234609,0.0003945344,0.000067719,0.0004067556,0.00406738,0.0003495174,0.01309503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005821152,"threshold_uncertainty_score":0.01947367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00494528553139187,"score_gpt":0.2256192885199174,"score_spread":0.2206740029885255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}