{"id":"W2933329466","doi":"10.1016/j.ijpharm.2019.04.004","title":"Amorphous pullulan trehalose microparticle platform for respiratory delivery","year":2019,"lang":"en","type":"article","venue":"International Journal of Pharmaceutics","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Killam Trusts; University of Alberta","keywords":"Pullulan; Dry-powder inhaler; Trehalose; Spray drying; Materials science; Inhaler; Chemical engineering; Aerosolization; Metered-dose inhaler; Microparticle; Inhalation; Chromatography; Chemistry; Organic chemistry; Polysaccharide; Asthma; Medicine; Anesthesia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003870258,0.0001166918,0.0002196983,0.0002587111,0.00003240807,0.00003404415,0.0002068793,0.00006984766,0.0003960914],"category_scores_gemma":[0.0000660084,0.0000974026,0.0002417218,0.00007400668,0.0000421676,0.0002129311,0.0000335316,0.0002457319,0.000124372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001802314,"about_ca_system_score_gemma":0.0002273577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001243845,"about_ca_topic_score_gemma":6.473298e-7,"domain_scores_codex":[0.9986504,0.00002296811,0.000544205,0.0001116972,0.0004993968,0.0001712973],"domain_scores_gemma":[0.9982324,0.0001017866,0.0003322412,0.0001058824,0.001063969,0.0001637485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003707579,0.0005297569,0.03095033,0.00007735336,0.0007114251,0.0004308642,0.0003705664,0.0005080571,0.9252564,0.000339755,0.005062429,0.03205545],"study_design_scores_gemma":[0.009699682,0.0004948314,0.001740578,0.0001347231,0.0001944351,0.0006785601,0.0002244129,0.003664333,0.5623325,0.00005435328,0.4206035,0.0001781258],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945809,0.0006157715,0.0003220545,0.0007788803,0.002616432,0.0002534496,0.00001748802,0.00001691995,0.0007981466],"genre_scores_gemma":[0.9927378,0.00007187028,0.0007929651,0.00471323,0.0009178868,0.000002279943,0.000006648045,0.00002405234,0.0007332357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4155411,"threshold_uncertainty_score":0.4336923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05496495246131369,"score_gpt":0.3632546902939293,"score_spread":0.3082897378326156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}