{"id":"W2933329466","doi":"10.1016/j.ijpharm.2019.04.004","title":"Amorphous pullulan trehalose microparticle platform for respiratory delivery","year":2019,"lang":"en","type":"article","venue":"International Journal of Pharmaceutics","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Killam Trusts; University of Alberta","keywords":"Pullulan; Dry-powder inhaler; Trehalose; Spray drying; Materials science; Inhaler; Chemical engineering; Aerosolization; Metered-dose inhaler; Microparticle; Inhalation; Chromatography; Chemistry; Organic chemistry; Polysaccharide; Asthma; Medicine; Anesthesia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007840162,0.0002341696,0.0001668477,0.0001799767,0.0001209273,0.0002652819,0.0001762374,0.0003565185,0.001164854],"category_scores_gemma":[0.00009154095,0.0001023971,0.000278129,0.000107959,0.00008489405,0.0002436792,0.0002079683,0.0004334916,0.000405481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001516246,"about_ca_system_score_gemma":0.0001628199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003984079,"about_ca_topic_score_gemma":0.0006423205,"domain_scores_codex":[0.9999294,0.000005361265,0.000004447138,0.00001859347,0.00002460612,0.00001765375],"domain_scores_gemma":[0.9999533,0.000007717224,0.00001511834,0.000003957626,0.000009404433,0.00001051226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005106221,0.00001966306,0.00004560186,0.00005258682,0.000005829349,0.00008170643,0.000008030413,0.0001666185,0.9961694,0.0001221624,0.00007197451,0.003205288],"study_design_scores_gemma":[0.0000107972,0.0003306314,0.0006068461,0.000006821425,0.00001898762,0.0001562766,0.00001267257,0.001618257,0.9947135,0.00003571823,0.002480809,0.000008637057],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9711555,0.003338089,0.02053769,0.0002071491,0.000118024,0.00009511733,0.0003860854,0.0002368951,0.003925443],"genre_scores_gemma":[0.986982,0.001265832,0.006324059,0.00006535345,0.00002684734,0.00004726477,0.0001523586,0.00002068112,0.005115455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001164854,"threshold_uncertainty_score":0.003896832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05496495246131369,"score_gpt":0.3632546902939293,"score_spread":0.3082897378326156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}