{"id":"W2933400096","doi":"10.12688/mniopenres.12816.1","title":"Generation of human midbrain organoids from induced pluripotent stem cells","year":2019,"lang":"en","type":"article","venue":"MNI Open Research","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"Québec Consortium for Drug Discovery; Canadian Institutes of Health Research; Parkinson Canada; Fonds de Recherche du Québec - Santé; Buck Institute for Research on Aging; Michael J. Fox Foundation for Parkinson's Research","keywords":"Organoid; Midbrain; Induced pluripotent stem cell; Biology; Neuroscience; Stem cell; Human Induced Pluripotent Stem Cells; Neuromelanin; Cell biology; Dopaminergic; Substantia nigra; Dopamine; Embryonic stem cell; Central nervous system; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001769123,0.0001717245,0.0002773336,0.000166045,0.0001779356,0.0001840818,0.001533923,0.000260451,0.0007270395],"category_scores_gemma":[0.00004132669,0.0001619681,0.00007953442,0.0003351022,0.0001098577,0.00001646309,0.001829987,0.000378361,0.0005051456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006995143,"about_ca_system_score_gemma":0.0002948445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001670226,"about_ca_topic_score_gemma":0.0002683196,"domain_scores_codex":[0.9966062,0.0007306645,0.0003761081,0.0007617252,0.0009449126,0.0005804184],"domain_scores_gemma":[0.9980564,0.00005266166,0.00008472972,0.00113171,0.00049548,0.0001790297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009623628,0.0001450123,0.003379601,0.00003397648,0.00006242095,0.000006618799,0.00009436631,0.00001219617,0.9891987,0.00009374891,0.005646172,0.001230878],"study_design_scores_gemma":[0.001001226,0.0007156477,0.001329491,0.00002736661,0.000003848987,0.000001107398,0.0003336371,0.0002532231,0.9903295,0.00003930715,0.005786277,0.0001793707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909427,0.0001862351,0.00002996573,0.0002315447,0.0001287338,0.001414732,0.00005961113,0.000006187076,0.007000359],"genre_scores_gemma":[0.9791499,0.00004934369,0.0001989959,0.00004888675,0.0002153367,0.00006399705,0.0002913598,0.00004688124,0.01993524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01293488,"threshold_uncertainty_score":0.7960572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1577355596544132,"score_gpt":0.3867562825717549,"score_spread":0.2290207229173417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}