{"id":"W2933400096","doi":"10.12688/mniopenres.12816.1","title":"Generation of human midbrain organoids from induced pluripotent stem cells","year":2019,"lang":"en","type":"article","venue":"MNI Open Research","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"Québec Consortium for Drug Discovery; Canadian Institutes of Health Research; Parkinson Canada; Fonds de Recherche du Québec - Santé; Buck Institute for Research on Aging; Michael J. Fox Foundation for Parkinson's Research","keywords":"Organoid; Midbrain; Induced pluripotent stem cell; Biology; Neuroscience; Stem cell; Human Induced Pluripotent Stem Cells; Neuromelanin; Cell biology; Dopaminergic; Substantia nigra; Dopamine; Embryonic stem cell; Central nervous system; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003676253,0.0003587848,0.0002193713,0.0004871624,0.0002975392,0.0003579146,0.0003533872,0.000341637,0.005274259],"category_scores_gemma":[0.0001590051,0.0002815875,0.0003347697,0.0002619517,0.0002557556,0.0002038071,0.0004310801,0.0006812127,0.00335186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002104807,"about_ca_system_score_gemma":0.0003094285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003646923,"about_ca_topic_score_gemma":0.0009849289,"domain_scores_codex":[0.9998134,0.00002294803,0.00003483252,0.00004113121,0.00006810543,0.00001967549],"domain_scores_gemma":[0.9998994,0.00002141786,0.00001447374,0.00002957112,0.0000195996,0.00001559504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005674027,0.00002138203,0.0001424108,0.0001076371,0.000007496143,0.0002120594,0.00009085931,0.0002476248,0.9899098,0.001042692,0.0008618633,0.007299404],"study_design_scores_gemma":[0.0000214938,0.0001199664,0.001367388,0.00003643318,0.00001722302,0.0004321579,0.00003910776,0.000980968,0.9529311,0.0002322964,0.04381154,0.00001032289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5217361,0.007460795,0.3578039,0.001120595,0.001176144,0.004264503,0.03293959,0.003292307,0.07020608],"genre_scores_gemma":[0.6550159,0.006648906,0.2550588,0.0004706382,0.00009614162,0.002940148,0.02815937,0.0006322755,0.05097787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005274259,"threshold_uncertainty_score":0.01764417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1577355596544132,"score_gpt":0.3867562825717549,"score_spread":0.2290207229173417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}