{"id":"W2933447091","doi":"10.1038/s41386-019-0383-y","title":"White matter microstructure is associated with hyperactive/inattentive symptomatology and polygenic risk for attention-deficit/hyperactivity disorder in a population-based sample of adolescents","year":2019,"lang":"en","type":"article","venue":"Neuropsychopharmacology","topic":"Attention Deficit Hyperactivity Disorder","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Holland Bloorview Kids Rehabilitation Hospital; McGill University; Montreal Neurological Institute and Hospital","funders":"Medical Research Council; National Institutes of Health; National Institute of Mental Health; Fondation pour la Recherche Médicale; Svenska Forskningsrådet Formas; Agence Nationale de la Recherche; Mission Interministérielle de Lutte Contre les Drogues et les Conduites Addictives; Eli Lilly and Company; Bristol-Myers Squibb; Science Foundation Ireland; South London and Maudsley NHS Foundation Trust; European Commission; Vifor Pharma; Vetenskapsrådet; Pfizer; Deutsche Forschungsgemeinschaft; King's College London; Fondation de France; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; National Institute of General Medical Sciences; Desitin Arzneimittel; Institut National de la Santé et de la Recherche Médicale; EU Joint Programme – Neurodegenerative Disease Research","keywords":"Attention deficit hyperactivity disorder; White matter; Fractional anisotropy; Psychology; Polygenic risk score; Neuroimaging; Population; Clinical psychology; Psychiatry; Magnetic resonance imaging; Medicine; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001531597,0.0003655849,0.0008259584,0.0004164926,0.00009693755,0.00001555876,0.0001098515,0.0002560767,0.0007157509],"category_scores_gemma":[0.0001514129,0.000341136,0.0001718352,0.0004557423,0.0001187076,0.0001975469,0.00004125967,0.0005737837,0.0000298833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008915861,"about_ca_system_score_gemma":0.00008397256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002956841,"about_ca_topic_score_gemma":0.0001613833,"domain_scores_codex":[0.9976445,0.0003611569,0.0004946577,0.0007789346,0.0002498236,0.0004709566],"domain_scores_gemma":[0.9980723,0.0006585595,0.0005635566,0.0003157179,0.0002841369,0.0001056926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002366443,0.0009842615,0.9730609,0.0001918894,0.0001991002,0.000008443832,0.00005761728,0.000132092,0.02276288,0.000003243809,0.00005686249,0.0001762413],"study_design_scores_gemma":[0.01552246,0.0004874481,0.9811571,0.0001244906,0.0003678767,0.00006478865,0.000161472,0.001744835,0.00003529068,0.00001638047,0.00003715837,0.0002807206],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956723,0.00005830206,0.0001889917,0.001100499,0.0004159412,0.001983973,0.0004998327,0.00004226986,0.00003789232],"genre_scores_gemma":[0.997871,0.00001815877,0.000223238,0.001319903,0.00002224944,0.0001020268,0.0002087508,0.00008718982,0.0001474812],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02272759,"threshold_uncertainty_score":0.999904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008718115289484926,"score_gpt":0.2902680803888817,"score_spread":0.2815499650993968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}