{"id":"W2933783237","doi":"10.1016/j.actbio.2019.04.010","title":"Immune tolerance of tissue-engineered skin produced with allogeneic or xenogeneic fibroblasts and syngeneic keratinocytes grafted on mice","year":2019,"lang":"en","type":"article","venue":"Acta Biomaterialia","topic":"Tissue Engineering and Regenerative Medicine","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"Institute of Musculoskeletal Health and Arthritis; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Fondation de l’Université Laval; Federal Aviation Administration; Centre Hospitalier Universitaire de Québec; Canada Research Chairs; Fondation des pompiers du Québec pour les grands brûlés","keywords":"Immune system; Materials science; Tissue engineering; Skin transplantation; Keratinocyte; Immunology; Immune tolerance; Cancer research; Transplantation; Cell biology; Cell culture; Biomedical engineering; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003829769,0.0005995233,0.000290962,0.0005776927,0.00018259,0.0003521112,0.000295659,0.0006126541,0.001927388],"category_scores_gemma":[0.000238864,0.0002095911,0.0004616803,0.0001557686,0.0003280106,0.0003632024,0.0002343051,0.0008950849,0.0003585653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001320279,"about_ca_system_score_gemma":0.0001340321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001255144,"about_ca_topic_score_gemma":0.0001101584,"domain_scores_codex":[0.9995586,0.00008105864,0.00004154012,0.0001168467,0.00009072806,0.0001111423],"domain_scores_gemma":[0.9996897,0.00006904429,0.00008755494,0.00006322895,0.00002676271,0.0000636898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006340726,0.0001160894,0.0001948677,0.00003412741,0.0000120549,0.0001295236,0.00002598479,0.0001062976,0.9975097,0.000317055,0.00001681994,0.0009033685],"study_design_scores_gemma":[0.00006218092,0.001384542,0.002459409,0.00001615272,0.00004798791,0.0006797525,0.00005539236,0.0006996833,0.9934872,0.0001735748,0.0009282648,0.00000582896],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956731,0.0006570254,0.001306404,0.00002989974,0.00006017669,0.00002937746,0.00008891732,0.00003065854,0.002124331],"genre_scores_gemma":[0.9974331,0.0003080827,0.0005575729,0.00004574845,0.00001529922,0.00002124099,0.0001121021,0.00001790828,0.001488962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001927388,"threshold_uncertainty_score":0.006447732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008385653278015345,"score_gpt":0.2347336274873137,"score_spread":0.2263479742092983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}