{"id":"W2933783237","doi":"10.1016/j.actbio.2019.04.010","title":"Immune tolerance of tissue-engineered skin produced with allogeneic or xenogeneic fibroblasts and syngeneic keratinocytes grafted on mice","year":2019,"lang":"en","type":"article","venue":"Acta Biomaterialia","topic":"Tissue Engineering and Regenerative Medicine","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"Institute of Musculoskeletal Health and Arthritis; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Fondation de l’Université Laval; Federal Aviation Administration; Centre Hospitalier Universitaire de Québec; Canada Research Chairs; Fondation des pompiers du Québec pour les grands brûlés","keywords":"Immune system; Materials science; Tissue engineering; Skin transplantation; Keratinocyte; Immunology; Immune tolerance; Cancer research; Transplantation; Cell biology; Cell culture; Biomedical engineering; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001323418,0.0003600181,0.0007089644,0.0001783591,0.00004267273,0.00002282889,0.0001115297,0.0001262745,0.0001946487],"category_scores_gemma":[0.00004321563,0.0002230107,0.00003734535,0.0003040099,0.00008046875,0.00005865407,0.00003599,0.00007909121,0.00002831544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003491574,"about_ca_system_score_gemma":0.00006368081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005663751,"about_ca_topic_score_gemma":0.000005574052,"domain_scores_codex":[0.9984972,0.00004846742,0.00039857,0.0004691439,0.0002652933,0.0003213543],"domain_scores_gemma":[0.9990977,0.00003600248,0.0001315985,0.0004930029,0.0001042155,0.0001374845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00126011,0.0001009351,0.0004130071,0.0006856601,0.0001812852,0.0000389543,0.000331163,0.00006471918,0.9961436,0.00002465136,0.0002460414,0.000509813],"study_design_scores_gemma":[0.002760213,0.002993803,0.02729832,0.0008156553,0.0000996766,0.0002124547,0.000041262,0.0001418758,0.963304,7.116682e-7,0.002059675,0.000272287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957002,0.001935362,0.00003380006,0.0004879383,0.0008129229,0.0008642472,0.00002870207,0.0001147358,0.00002204632],"genre_scores_gemma":[0.9940446,0.00007070331,0.001355523,0.00002999899,0.0002984998,0.00003587544,0.00008563665,0.0000693026,0.004009838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0328396,"threshold_uncertainty_score":0.9094113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008385653278015345,"score_gpt":0.2347336274873137,"score_spread":0.2263479742092983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}