{"id":"W2934039904","doi":"10.3390/cells8040290","title":"Hepatitis C Virus Non-Structural Protein 5A (NS5A) Disrupts Mitochondrial Dynamics and Induces Mitophagy","year":2019,"lang":"en","type":"article","venue":"Cells","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University","funders":"Ministry of Science and Technology, Taiwan","keywords":"Mitophagy; NS5A; Autophagy; Cell biology; Parkin; Mitochondrion; Biology; Hepatitis C virus; Biochemistry; Virology; Virus; Hepacivirus; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003310086,0.0001986446,0.0003112761,0.00006320637,0.00006173835,0.00003694154,0.00009819677,0.0001475125,0.0007026867],"category_scores_gemma":[0.00001014996,0.0001656856,0.00008798507,0.00009585893,0.00008333607,0.0001122736,0.00004718936,0.0001892303,0.0002303507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005556069,"about_ca_system_score_gemma":0.00007273036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002995212,"about_ca_topic_score_gemma":0.00005586097,"domain_scores_codex":[0.9989567,0.00002726833,0.0002033449,0.0003231746,0.0002214259,0.000268048],"domain_scores_gemma":[0.9993359,0.00002838702,0.00007998641,0.0003262091,0.00004264673,0.0001868121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004072285,0.00009313208,0.01716217,0.0002052377,0.0001368665,0.0001640915,0.0004744286,0.000002423503,0.9689963,0.0003266437,0.0005127941,0.01151871],"study_design_scores_gemma":[0.004398437,0.0006578061,0.1277034,0.0001980419,0.00009334508,0.00004721938,0.00009390027,0.003183169,0.8613665,0.000885218,0.0009313967,0.0004415531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960796,0.0004438017,0.00002962468,0.0001126839,0.001003518,0.0009418243,0.00005160196,0.00004915782,0.001288252],"genre_scores_gemma":[0.9940616,0.0001457702,0.000509246,0.0002868595,0.0004706719,0.00002909524,0.00005695435,0.00003386887,0.00440587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1105412,"threshold_uncertainty_score":0.7693926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004550627483124191,"score_gpt":0.2387214493133327,"score_spread":0.2341708218302085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}