{"id":"W2934039904","doi":"10.3390/cells8040290","title":"Hepatitis C Virus Non-Structural Protein 5A (NS5A) Disrupts Mitochondrial Dynamics and Induces Mitophagy","year":2019,"lang":"en","type":"article","venue":"Cells","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University","funders":"Ministry of Science and Technology, Taiwan","keywords":"Mitophagy; NS5A; Autophagy; Cell biology; Parkin; Mitochondrion; Biology; Hepatitis C virus; Biochemistry; Virology; Virus; Hepacivirus; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000141087,0.0002751295,0.0002419282,0.0001723732,0.0001892147,0.0002136729,0.00009103067,0.0002194546,0.0005271972],"category_scores_gemma":[0.00008818309,0.00009630369,0.0003058066,0.0001382149,0.0001922854,0.0001415711,0.0001943895,0.000355134,0.0001232322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003280809,"about_ca_system_score_gemma":0.0002129259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008561886,"about_ca_topic_score_gemma":0.001332853,"domain_scores_codex":[0.9998693,0.00003304093,0.00001740245,0.00001741035,0.00003000068,0.00003275343],"domain_scores_gemma":[0.9999423,0.00001393303,0.00001565559,0.00000902059,0.000005798111,0.00001327667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000113628,0.00003404544,0.0001466773,0.0000385254,0.000005931779,0.0000502112,0.00001206337,0.00005265863,0.9986167,0.00009099697,0.00002681569,0.0008116303],"study_design_scores_gemma":[0.00001422462,0.0004323779,0.006655403,0.000007390229,0.00001241592,0.0001600852,0.00002086742,0.001138301,0.9902948,0.00004809847,0.001212109,0.000004058659],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947327,0.00180112,0.001808665,0.00009252714,0.00003526786,0.00002762019,0.0001700407,0.00005953169,0.001272594],"genre_scores_gemma":[0.9976509,0.0006882378,0.0007883732,0.00003580472,0.0000048731,0.00001654882,0.0001606334,0.000005955379,0.0006486985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008561886,"threshold_uncertainty_score":0.002380371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004550627483124191,"score_gpt":0.2387214493133327,"score_spread":0.2341708218302085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}