{"id":"W2934332834","doi":"10.1126/scisignal.aav0711","title":"TRPV1 promotes opioid analgesia during inflammation","year":2019,"lang":"en","type":"article","venue":"Science Signaling","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Alberta Children's Hospital","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; Agence Nationale de la Recherche","keywords":"TRPV1; Opioid; Inflammation; Pharmacology; Medicine; Internal medicine; Receptor; Transient receptor potential channel","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001339418,0.0002218181,0.0002630161,0.0001750332,0.000176731,0.0003346319,0.0001735527,0.0003104853,0.001884116],"category_scores_gemma":[0.0001405762,0.00009068489,0.0002616492,0.0001061751,0.0002308104,0.0003658116,0.0002756807,0.0006993088,0.0003298064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002486799,"about_ca_system_score_gemma":0.0001809851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002242004,"about_ca_topic_score_gemma":0.0003919558,"domain_scores_codex":[0.9998406,0.00001889219,0.000008338724,0.00003313199,0.00003279443,0.000066251],"domain_scores_gemma":[0.9999208,0.000007787846,0.00003150912,0.000005447765,0.00001081444,0.0000236296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001320978,0.00001573722,0.000157792,0.000100109,0.000003448165,0.00006198827,0.00001757785,0.00005261734,0.9973665,0.0003692683,0.00009174622,0.001631167],"study_design_scores_gemma":[0.00006452121,0.001234172,0.05954193,0.0001303951,0.00007129447,0.001426994,0.0001899225,0.00263379,0.9152316,0.001499007,0.01794225,0.00003421729],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9526394,0.02854256,0.009570731,0.0008861703,0.0002814945,0.00006247632,0.0004788508,0.0003338626,0.007204439],"genre_scores_gemma":[0.990754,0.005160572,0.0009859293,0.0001846892,0.00005519879,0.00002951455,0.0001857275,0.00001683227,0.002627624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001884116,"threshold_uncertainty_score":0.006302953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01623867858170229,"score_gpt":0.249798886675657,"score_spread":0.2335602080939547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}