{"id":"W2934332834","doi":"10.1126/scisignal.aav0711","title":"TRPV1 promotes opioid analgesia during inflammation","year":2019,"lang":"en","type":"article","venue":"Science Signaling","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Alberta Children's Hospital","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; Agence Nationale de la Recherche","keywords":"TRPV1; Opioid; Inflammation; Pharmacology; Medicine; Internal medicine; Receptor; Transient receptor potential channel","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005218542,0.0001092244,0.000105626,0.000236598,0.0004660305,0.0001878862,0.0004334946,0.00003719888,0.0003060909],"category_scores_gemma":[0.0002509422,0.00008834418,0.00004490074,0.001042824,0.0002300049,0.0007961079,0.00009340972,0.0001222712,0.0004077223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000581823,"about_ca_system_score_gemma":0.0001100524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005753154,"about_ca_topic_score_gemma":3.382233e-7,"domain_scores_codex":[0.9982765,0.00003605638,0.0001932366,0.0004846404,0.0006001258,0.0004094116],"domain_scores_gemma":[0.9995342,0.00005267028,0.00009998104,0.000153028,0.00005860337,0.0001014836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000004336744,0.000006944447,0.0002436348,0.00001824547,3.465831e-7,0.00000273272,0.0005657687,0.00106804,0.9967616,0.0005850766,0.000001575976,0.0007417073],"study_design_scores_gemma":[0.0001422434,0.00003298842,0.0004109134,0.00004669375,0.000001425984,0.00001147536,0.0001561367,0.005915275,0.9925867,0.0004823639,0.00007601408,0.0001378239],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966631,0.00001103197,0.0001126305,0.0001582925,0.0008510738,0.0002416629,9.29421e-7,0.00009608009,0.001865229],"genre_scores_gemma":[0.9989986,0.00000559347,0.0001872353,0.00004634711,0.0001722157,0.000005551217,3.637872e-7,0.000009549676,0.0005745406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004847235,"threshold_uncertainty_score":0.5240582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01623867858170229,"score_gpt":0.249798886675657,"score_spread":0.2335602080939547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}