{"id":"W2934729452","doi":"10.1002/hep.30631","title":"Hepatocyte Nuclear Factor 4‐Alpha Is Essential for the Active Epigenetic State at Enhancers in Mouse Liver","year":2019,"lang":"en","type":"article","venue":"Hepatology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Genome British Columbia; Canada's Michael Smith Genome Sciences Centre; Terry Fox Research Institute; University of British Columbia","funders":"Medical Research Council; National Cancer Institute; National Institutes of Health; Canadian Institutes of Health Research; Terry Fox Foundation; Genome British Columbia","keywords":"Histone; Epigenetics; Enhancer; Transcription factor; Epigenomics; Hepatocyte nuclear factors; Biology; Cell biology; DNA methylation; Hepatocyte nuclear factor 4; Molecular biology; Chemistry; Gene expression; DNA; Genetics; Gene; Nuclear receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001646067,0.0002574673,0.0001500427,0.0004339838,0.0001677017,0.000232658,0.0002405309,0.0001918781,0.001367181],"category_scores_gemma":[0.000143609,0.0002931363,0.0002294844,0.0001562929,0.0002993699,0.0001418412,0.0002281547,0.000314861,0.000574753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003755224,"about_ca_system_score_gemma":0.000231431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000857329,"about_ca_topic_score_gemma":0.001442808,"domain_scores_codex":[0.9998159,0.00002339331,0.00001376552,0.00004518482,0.00006038542,0.00004146443],"domain_scores_gemma":[0.9997354,0.00002694192,0.0001039289,0.00003802261,0.00002624097,0.00006947567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006341928,0.000005146193,0.0003807758,0.000009627281,0.000001931693,0.00002318143,0.000005796646,0.00002027779,0.9988147,0.00006292911,0.00001096035,0.0006011669],"study_design_scores_gemma":[0.00001586152,0.00008758401,0.01876417,0.000005971898,0.00001602415,0.0002331101,0.00001927307,0.0004087533,0.9781836,0.0001100578,0.002152036,0.000003699241],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990604,0.00143944,0.005818843,0.00008685407,0.00002226287,0.00001635997,0.000428438,0.0002594079,0.001324369],"genre_scores_gemma":[0.9932184,0.0003810913,0.002074892,0.00002846149,0.000006470366,0.00002256929,0.0005922472,0.00004972315,0.003626092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001367181,"threshold_uncertainty_score":0.004573703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01075556542171937,"score_gpt":0.2537670448806545,"score_spread":0.2430114794589352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}