{"id":"W2935101654","doi":"10.3390/v11040326","title":"Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir","year":2019,"lang":"en","type":"article","venue":"Viruses","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":657,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Gilead Sciences","keywords":"Ebola virus; Virology; RNA; Polymerase; RNA polymerase; Mechanism (biology); RNA-dependent RNA polymerase; Virus; Biology; DNA; Genetics; Gene; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003130963,0.0007393841,0.0004184078,0.0002702647,0.0001177955,0.0003441305,0.0006175596,0.0003867972,0.001578598],"category_scores_gemma":[0.0002011773,0.0003057209,0.0006456652,0.00008220252,0.0001791641,0.0002914198,0.0001835359,0.0005018206,0.0008715575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004648011,"about_ca_system_score_gemma":0.0001781522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004471784,"about_ca_topic_score_gemma":0.0003689143,"domain_scores_codex":[0.9997835,0.00004749479,0.00001709951,0.00005253716,0.00004509549,0.00005448006],"domain_scores_gemma":[0.9999293,0.00002435047,0.00001514533,0.000008977854,0.00001354069,0.00000862897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002325902,0.00006330985,0.0001564488,0.0001439264,0.000024558,0.00008531492,0.00001401623,0.000517262,0.9927106,0.000432106,0.0001249683,0.005494969],"study_design_scores_gemma":[0.00003244345,0.0006851324,0.0008711782,0.00001118937,0.00001581837,0.0002384018,0.000007554425,0.002726485,0.9930566,0.00007664938,0.002270243,0.000008385368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9315268,0.02133993,0.02738631,0.0003258426,0.000198749,0.0006195078,0.001548806,0.0006557531,0.01639838],"genre_scores_gemma":[0.9822215,0.003904356,0.006850213,0.0001588822,0.00002822527,0.0002053315,0.0008307628,0.00003854682,0.005762132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001578598,"threshold_uncertainty_score":0.005280912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02485196304339737,"score_gpt":0.307596575026299,"score_spread":0.2827446119829016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}