{"id":"W2935101654","doi":"10.3390/v11040326","title":"Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir","year":2019,"lang":"en","type":"article","venue":"Viruses","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":657,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Gilead Sciences","keywords":"Ebola virus; Virology; RNA; Polymerase; RNA polymerase; Mechanism (biology); RNA-dependent RNA polymerase; Virus; Biology; DNA; Genetics; Gene; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002106466,0.0001155883,0.000298678,0.0002042749,0.00003424446,0.000009296115,0.00005627868,0.00009955662,0.0006131317],"category_scores_gemma":[0.00004717691,0.00009647734,0.0001010217,0.0002110669,0.0000594281,0.0001350792,0.00005881964,0.0001634009,0.0002270885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004046813,"about_ca_system_score_gemma":0.0000773208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00228739,"about_ca_topic_score_gemma":0.0000284133,"domain_scores_codex":[0.998839,0.00005587478,0.0003189331,0.000190725,0.0004013639,0.000194071],"domain_scores_gemma":[0.9993299,0.00005235781,0.0001226359,0.0002792158,0.0001216535,0.00009429053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002004223,0.000292171,0.0003861024,0.0001048894,0.00004929335,0.000007954011,0.00005476005,0.000001451988,0.9931291,0.001420186,0.001262891,0.003090729],"study_design_scores_gemma":[0.001112859,0.0006957456,0.0003661023,0.0001250343,0.00003012833,0.00001163277,0.00009770742,0.00004722652,0.9959856,0.000197487,0.001244296,0.00008613573],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945316,0.000515494,0.0003316312,0.00009687238,0.0001270905,0.0003409343,0.0001162435,0.00006931682,0.003870773],"genre_scores_gemma":[0.9982762,0.0002894315,0.00006411385,0.0003110115,0.00005144065,0.00001070391,0.00001195887,0.00003735283,0.000947793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00374455,"threshold_uncertainty_score":0.6713362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02485196304339737,"score_gpt":0.307596575026299,"score_spread":0.2827446119829016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}