{"id":"W2935205376","doi":"10.1634/theoncologist.2018-0621","title":"Pantoprazole Affecting Docetaxel Resistance Pathways via Autophagy (PANDORA): Phase II Trial of High Dose Pantoprazole (Autophagy Inhibitor) with Docetaxel in Metastatic Castration-Resistant Prostate Cancer (mCRPC)","year":2019,"lang":"en","type":"article","venue":"The Oncologist","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"Docetaxel; Pantoprazole; Autophagy; Medicine; Prostate cancer; Oncology; Internal medicine; Cancer; Pharmacology; Cancer research; Chemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008291329,0.0008776748,0.0007680038,0.0003817469,0.0003100543,0.0007480376,0.0005860231,0.0007286564,0.002357121],"category_scores_gemma":[0.0004365597,0.0004345176,0.0008369524,0.0004068166,0.0007700091,0.0005198836,0.0002764408,0.001486569,0.0003689218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007894728,"about_ca_system_score_gemma":0.001441046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001184747,"about_ca_topic_score_gemma":0.004481348,"domain_scores_codex":[0.9997814,0.00009265399,0.000013814,0.00003634148,0.00002232603,0.00005350816],"domain_scores_gemma":[0.9997409,0.00003240227,0.00005887231,0.00001876794,0.00001679932,0.0001322335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6025242,0.05873339,0.01212241,0.002016957,0.002180207,0.0004387971,0.0004933805,0.005943628,0.07076337,0.0008114318,0.005738468,0.2382338],"study_design_scores_gemma":[0.4650871,0.49354,0.024692,0.00008796462,0.000826545,0.0006839561,0.00009312107,0.002398013,0.007606009,0.0002341378,0.004699168,0.00005199672],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963683,0.001356471,0.0001585219,0.000223124,0.00004413394,0.0006695317,0.0002804052,0.00005899503,0.0008405201],"genre_scores_gemma":[0.9950731,0.001241285,0.0007997939,0.0002427349,0.00005655352,0.0006256332,0.0007261824,0.00001034266,0.001224334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002357121,"threshold_uncertainty_score":0.007885396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02419300714168803,"score_gpt":0.3156571043337689,"score_spread":0.2914640971920809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}