{"id":"W2935356429","doi":"10.1093/annonc/mdz112","title":"T-cell bispecific antibodies in node-positive breast cancer: novel therapeutic avenue for MHC class I loss variants","year":2019,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Direction Générale de l’offre de Soins; Ligue Contre le Cancer; Agence Nationale de la Recherche; National Institute for Health and Care Research; Fondation ISREC; Institut National Du Cancer; Cancer Research UK; Swiss Bridge Foundation; Wellcome Trust; Roche","keywords":"Medicine; Cancer research; Major histocompatibility complex; Immune system; Immunology; Breast cancer; MHC class I; Antibody; T cell; Cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001741586,0.0002680526,0.0001951148,0.000121951,0.0001132228,0.0003417716,0.000331236,0.0002715717,0.001657733],"category_scores_gemma":[0.00008875388,0.00009244951,0.0001567661,0.0001312291,0.0001709619,0.0002407673,0.00020568,0.0008381695,0.000307558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002620434,"about_ca_system_score_gemma":0.0002077307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003022265,"about_ca_topic_score_gemma":0.0006089746,"domain_scores_codex":[0.9999524,0.000008028128,0.000001779969,0.000007265007,0.000005962551,0.00002447517],"domain_scores_gemma":[0.9999797,0.000004864574,0.0000043972,0.000002755684,0.000002569825,0.000005634595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002366859,0.001238603,0.001800404,0.0004141362,0.00008262767,0.0006448768,0.0001344122,0.001824479,0.7576054,0.008256765,0.005091672,0.2205397],"study_design_scores_gemma":[0.003802513,0.020364,0.01718638,0.0002653616,0.0007695705,0.009159639,0.0003367945,0.01149745,0.6773782,0.007340665,0.251835,0.0000643619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9308027,0.03826597,0.01091001,0.002049247,0.000442453,0.0001947089,0.00026736,0.0002512958,0.01681636],"genre_scores_gemma":[0.9792114,0.01349227,0.002877775,0.0005522852,0.000114192,0.0001052634,0.0002129647,0.00002999064,0.003403882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001657733,"threshold_uncertainty_score":0.005545616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03926484848163735,"score_gpt":0.3287131254605979,"score_spread":0.2894482769789605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}