{"id":"W2935613324","doi":"10.1016/j.celrep.2019.03.002","title":"Histone H3K9 Methyltransferase G9a in Oocytes Is Essential for Preimplantation Development but Dispensable for CG Methylation Protection","year":2019,"lang":"en","type":"article","venue":"Cell Reports","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Okanagan University College; University of British Columbia, Okanagan Campus; University of British Columbia","funders":"Japan Society for the Promotion of Science; Canadian Institutes of Health Research; Genome British Columbia","keywords":"Biology; Histone methyltransferase; Methylation; Epigenetics; Histone methylation; Methyltransferase; Chromatin; Cell biology; EZH2; Histone; DNA methylation; Oocyte; Zygote; Epigenomics; Genetics; Embryo; Embryogenesis; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005041769,0.0001448899,0.0001628962,0.00007903876,0.00007552267,0.00002462788,0.00004453392,0.0001695767,0.00002115933],"category_scores_gemma":[0.00006638149,0.0001520679,0.00008482203,0.0000691461,0.000013436,0.00001108381,0.00001546461,0.00004751057,0.000003150268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005398274,"about_ca_system_score_gemma":0.0001317911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005289228,"about_ca_topic_score_gemma":0.00007149839,"domain_scores_codex":[0.9987227,0.00003228343,0.0004493564,0.0004596073,0.0001293066,0.0002067215],"domain_scores_gemma":[0.9993527,0.00002584988,0.0001983662,0.0002280598,0.0001500197,0.00004502821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001806588,0.00006781016,0.001327728,0.0001560706,0.00001753848,0.000001335799,0.0001599871,0.0006705426,0.9919135,0.000006044964,0.00004885952,0.005449934],"study_design_scores_gemma":[0.0006447647,0.0001967734,0.001477047,0.00001347233,0.00002348738,0.000003912718,0.0000314001,0.0006146276,0.9750895,0.00040365,0.02130705,0.0001943095],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8475074,0.0004967831,0.1496081,0.00003030093,0.0003374769,0.001732031,0.0000107618,0.000009582151,0.0002676178],"genre_scores_gemma":[0.9886749,0.0000674959,0.007698304,0.0000228988,0.0001007676,0.0004213453,0.0007425818,0.00002862129,0.002243057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1419098,"threshold_uncertainty_score":0.6201149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01463933078113794,"score_gpt":0.2762009966435908,"score_spread":0.2615616658624529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}