{"id":"W2935613324","doi":"10.1016/j.celrep.2019.03.002","title":"Histone H3K9 Methyltransferase G9a in Oocytes Is Essential for Preimplantation Development but Dispensable for CG Methylation Protection","year":2019,"lang":"en","type":"article","venue":"Cell Reports","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Okanagan University College; University of British Columbia, Okanagan Campus; University of British Columbia","funders":"Japan Society for the Promotion of Science; Canadian Institutes of Health Research; Genome British Columbia","keywords":"Biology; Histone methyltransferase; Methylation; Epigenetics; Histone methylation; Methyltransferase; Chromatin; Cell biology; EZH2; Histone; DNA methylation; Oocyte; Zygote; Epigenomics; Genetics; Embryo; Embryogenesis; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001072368,0.0002755265,0.0002714707,0.0001980505,0.0002159681,0.0004206201,0.0003025326,0.0003104122,0.001541478],"category_scores_gemma":[0.0001588312,0.0001878829,0.0002186657,0.0001273079,0.0002843376,0.0002362104,0.0003588129,0.0004966879,0.0007299118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003195266,"about_ca_system_score_gemma":0.0003473365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009402533,"about_ca_topic_score_gemma":0.001818771,"domain_scores_codex":[0.9998668,0.0000149866,0.00001137726,0.00004569083,0.00003328145,0.00002783167],"domain_scores_gemma":[0.9998473,0.00002397057,0.00004327887,0.00002796528,0.00001279007,0.00004478297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000442021,0.000002928045,0.0003062245,0.00001511212,0.000003161844,0.00004376278,0.000005422957,0.00001470567,0.9987544,0.00008383238,0.00001520944,0.0007111211],"study_design_scores_gemma":[0.00001475256,0.00008474434,0.01927046,0.000007148077,0.00001524212,0.0003700453,0.00002716616,0.0002720914,0.9764588,0.0001575088,0.003316801,0.000005175722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840555,0.003672502,0.00700275,0.0002121995,0.00006082772,0.00002365398,0.001043938,0.0002685811,0.003660029],"genre_scores_gemma":[0.9933657,0.000763728,0.001912529,0.00006003701,0.000009327814,0.0000142147,0.0008831507,0.00006908023,0.0029222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001541478,"threshold_uncertainty_score":0.005156696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01463933078113794,"score_gpt":0.2762009966435908,"score_spread":0.2615616658624529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}