{"id":"W2935738470","doi":"10.1096/fj.201802293rr","title":"4‐Phenylbutyrate protects against atherosclerotic lesion growth by increasing the expression of HSP25 in macrophages and in the circulation of <i>Apoe</i> <sup>−/−</sup> mice","year":2019,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Libin Cardiovascular Institute of Alberta; Hamilton Health Sciences; University of Calgary; St. Joseph’s Healthcare Hamilton","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Hsp27; Heat shock protein; Monocyte; Apolipoprotein E; Internal medicine; Endocrinology; Lesion; Macrophage; Apolipoprotein B; Hsp70; Chemistry; Small interfering RNA; Biology; Immunology; Medicine; Pathology; In vitro; Cholesterol; Biochemistry; Transfection; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001918278,0.0007927751,0.0004578491,0.0005676124,0.0002439454,0.0003388342,0.0002504419,0.0004532164,0.001487717],"category_scores_gemma":[0.0001014918,0.0003697493,0.0004471978,0.0001943686,0.0004880971,0.0002738872,0.0001682061,0.001288189,0.0004606601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002789103,"about_ca_system_score_gemma":0.0002504959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009366093,"about_ca_topic_score_gemma":0.001213114,"domain_scores_codex":[0.9998356,0.00002954888,0.00002016654,0.00003886646,0.00003253487,0.00004326533],"domain_scores_gemma":[0.9997409,0.00001639886,0.00009483814,0.00002606592,0.00002672511,0.00009504187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006015503,0.0000899627,0.0001419627,0.00001844881,0.000005570061,0.00001557836,0.000008165781,0.00002273093,0.998681,0.00001579172,0.00002285699,0.0003762688],"study_design_scores_gemma":[0.0001190937,0.002052714,0.009207756,0.00001083663,0.00005100888,0.0001093932,0.00006363675,0.0003960017,0.9870025,0.00005394989,0.0009210196,0.00001214188],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965343,0.000591502,0.001334962,0.0001954499,0.00004184064,0.0000342348,0.0007430554,0.0001215002,0.0004031532],"genre_scores_gemma":[0.9878421,0.001102129,0.003395062,0.0002715468,0.00004072688,0.0001719631,0.001285164,0.0001142441,0.00577709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001487717,"threshold_uncertainty_score":0.004976988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01323472573921763,"score_gpt":0.2509335575224998,"score_spread":0.2376988317832822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}