{"id":"W2935754753","doi":"10.3389/fonc.2019.00288","title":"Germline Predisposition and Copy Number Alteration in Pre-stage Lung Adenocarcinomas Presenting as Ground-Glass Nodules","year":2019,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; University of Manitoba; Research Institute in Oncology and Hematology","funders":"National Cancer Institute; Shanghai Hospital Development Center; Western Canada Research Grid; CancerCare Manitoba Foundation","keywords":"Stage (stratigraphy); Germline; Adenocarcinoma; Lung; Germline mutation; Biology; Cancer research; Medicine; Pathology; Internal medicine; Cancer; Mutation; Genetics; Paleontology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002140306,0.0002280368,0.0001636494,0.0009756869,0.0002577699,0.000256432,0.0001957089,0.0003061648,0.002291634],"category_scores_gemma":[0.001245761,0.0001309806,0.0001816284,0.0005031358,0.0002529571,0.0002092174,0.0002278679,0.0001615543,0.0001854633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001579246,"about_ca_system_score_gemma":0.0001575447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001247607,"about_ca_topic_score_gemma":0.00162917,"domain_scores_codex":[0.999815,0.00002163018,0.00001965454,0.00006554402,0.00004296936,0.00003507699],"domain_scores_gemma":[0.999514,0.0001308534,0.0001948134,0.00003224432,0.00003957746,0.00008855142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001411056,0.00001466688,0.9877346,0.00001271892,0.0000233864,0.001736443,0.00006208271,0.000084418,0.007653058,0.00003367896,0.00003309032,0.002470727],"study_design_scores_gemma":[0.000003769633,0.00008527519,0.9933921,0.000002913585,0.00002280897,0.004810276,0.00007687399,0.0003878095,0.001067307,0.00005030061,0.00009746807,0.000003183726],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996475,0.00009514389,0.00006942353,0.000007046197,0.000001623283,0.000003098767,0.00003865413,0.000003475688,0.0001339924],"genre_scores_gemma":[0.9998494,0.00002176242,0.00004578394,0.000002502434,0.000002345436,0.000001253282,0.00003088746,6.50479e-7,0.0000452388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002291634,"threshold_uncertainty_score":0.00766623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004631430151260347,"score_gpt":0.2683459350581265,"score_spread":0.2637145049068662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}