{"id":"W2935828585","doi":"10.1039/c9tb00325h","title":"Gold nanoparticle–protein conjugate dually-responsive to pH and temperature for modulation of enzyme activity","year":2019,"lang":"en","type":"article","venue":"Journal of Materials Chemistry B","topic":"Polymer Surface Interaction Studies","field":"Materials Science","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"NIH Clinical Center; National Natural Science Foundation of China","keywords":"Conjugate; Nanoparticle; Colloidal gold; Materials science; Enzyme; Atmospheric temperature range; Modulation (music); Polymer; Enzyme assay; Dual (grammatical number); Biophysics; Chemical engineering; Nanotechnology; Chemistry; Biochemistry; Thermodynamics; Composite material; Physics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000572232,0.0001370809,0.000416211,0.00002745274,0.0000330727,0.000072895,0.0001239262,0.00007809147,0.0003557472],"category_scores_gemma":[0.0003072392,0.0001148981,0.00005086841,0.00005335572,0.00004269499,0.0002938349,0.00008571157,0.00005975538,0.00001540864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004516655,"about_ca_system_score_gemma":0.00004875242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001126123,"about_ca_topic_score_gemma":7.519537e-7,"domain_scores_codex":[0.9989216,0.00006255883,0.0004595778,0.0001647699,0.0002229592,0.0001685509],"domain_scores_gemma":[0.9987597,0.0001220738,0.0005939618,0.0001546571,0.0002863659,0.00008325501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001631467,0.00003950171,0.00004530432,0.0001430188,0.00002692826,0.000002514892,0.0001957406,0.00008826335,0.9973269,0.000003896623,0.0004626777,0.00003381863],"study_design_scores_gemma":[0.0006784712,0.000137734,0.0008203266,0.0001399043,0.00002005641,0.00003713558,0.00009004355,0.000008121197,0.9974715,0.00004298661,0.000440185,0.0001135906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985576,0.00005252062,0.00001723507,0.0005253305,0.0004693267,0.0002371602,0.00008621289,0.000009112287,0.00004555834],"genre_scores_gemma":[0.9983067,0.000003516454,0.0006561681,0.00004777848,0.0001185596,0.00001058759,8.544228e-7,0.00001327419,0.000842559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009529958,"threshold_uncertainty_score":0.468541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01102015064108788,"score_gpt":0.2615430710252413,"score_spread":0.2505229203841535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}