{"id":"W2935850363","doi":"10.2337/db18-0999","title":"Statins Promote Interleukin-1β–Dependent Adipocyte Insulin Resistance Through Lower Prenylation, Not Cholesterol","year":2019,"lang":"en","type":"article","venue":"Diabetes","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre; McMaster University; Population Health Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Insulin resistance; Internal medicine; Adipose tissue; Atorvastatin; Endocrinology; Inflammasome; Statin; Lipogenesis; Adipocyte; Insulin; Insulin receptor; Biology; Medicine; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004686439,0.0002271706,0.0004890012,0.00006329884,0.00006814996,0.0000502216,0.0001428858,0.0001233818,0.0002792521],"category_scores_gemma":[0.00009099999,0.0001909222,0.0002066563,0.0001772897,0.00004629018,0.0002423532,0.00006201395,0.0002974327,0.00044416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001385084,"about_ca_system_score_gemma":0.0001342631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005020577,"about_ca_topic_score_gemma":0.00003638367,"domain_scores_codex":[0.9979504,0.00008773224,0.0004059601,0.000482806,0.0006251092,0.0004479898],"domain_scores_gemma":[0.9986118,0.00003726151,0.0001378125,0.0008910429,0.0001793913,0.0001427086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003509156,0.004262649,0.3879258,0.01527321,0.006468119,0.0003435126,0.02435104,0.0002783083,0.2489784,0.004721367,0.01029614,0.2935923],"study_design_scores_gemma":[0.0113973,0.001743853,0.3338925,0.002211902,0.0004399339,0.00001660697,0.0002554472,0.0003650378,0.4392408,0.0008750837,0.2085374,0.001024183],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914929,0.001458952,0.0001338546,0.0007945927,0.0004189133,0.001354223,0.00003317136,0.000115278,0.00419817],"genre_scores_gemma":[0.9923581,0.00009627687,0.001200695,0.001594121,0.0002904066,0.00009288313,0.000059265,0.0000522572,0.004256002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2925681,"threshold_uncertainty_score":0.7785581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01080108690048777,"score_gpt":0.2474916561446704,"score_spread":0.2366905692441826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}