{"id":"W2935850363","doi":"10.2337/db18-0999","title":"Statins Promote Interleukin-1β–Dependent Adipocyte Insulin Resistance Through Lower Prenylation, Not Cholesterol","year":2019,"lang":"en","type":"article","venue":"Diabetes","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre; McMaster University; Population Health Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Insulin resistance; Internal medicine; Adipose tissue; Atorvastatin; Endocrinology; Inflammasome; Statin; Lipogenesis; Adipocyte; Insulin; Insulin receptor; Biology; Medicine; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002769458,0.0003526759,0.0004588265,0.00028627,0.0001624161,0.0004380318,0.0001537765,0.0003233085,0.002712936],"category_scores_gemma":[0.0002418189,0.0002042674,0.0005010649,0.0002170166,0.0002585191,0.0003814308,0.0003191369,0.0008530811,0.0004719482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002465608,"about_ca_system_score_gemma":0.0003318058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004805976,"about_ca_topic_score_gemma":0.001068358,"domain_scores_codex":[0.9997248,0.00005334357,0.00004402353,0.00005116974,0.00006528477,0.00006143262],"domain_scores_gemma":[0.9997796,0.0000271695,0.00009368925,0.00003144338,0.00003197975,0.00003618303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008697787,0.00005157058,0.0006353204,0.0001311821,0.00002573882,0.0000650974,0.00001875461,0.00004131238,0.994568,0.0001968159,0.00009376215,0.003302668],"study_design_scores_gemma":[0.0001961171,0.001330287,0.01466545,0.00003435238,0.0001108366,0.0005024566,0.00005578245,0.0005459886,0.9744326,0.0003928521,0.00771645,0.00001679801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.971566,0.01333558,0.007681589,0.001142054,0.0002219749,0.0001298545,0.001178112,0.0003959026,0.004348834],"genre_scores_gemma":[0.9875826,0.005523653,0.003036121,0.0004782263,0.00003893514,0.00005795298,0.0006300111,0.00003798931,0.00261456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002712936,"threshold_uncertainty_score":0.009075701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01080108690048777,"score_gpt":0.2474916561446704,"score_spread":0.2366905692441826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}