{"id":"W2935983171","doi":"10.1002/1878-0261.12493","title":"Biochemical pathways mediated by <scp>KLK</scp>6 protease in breast cancer","year":2019,"lang":"en","type":"article","venue":"Molecular Oncology","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"General Secretariat for Research and Technology; University of Patras","keywords":"Breast cancer; Cancer research; Proteomics; Apoptosis; Cancer; Downregulation and upregulation; Flow cytometry; Proteases; Biology; Molecular biology; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001943664,0.0002640395,0.000318418,0.00007786196,0.00003101003,0.00001677124,0.0003130843,0.0005322114,0.0001093241],"category_scores_gemma":[0.00008309374,0.0002566922,0.0001208906,0.0002035681,0.0001014576,0.000004914638,0.0001932225,0.0002617131,0.0001132756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008601575,"about_ca_system_score_gemma":0.0003193258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001495196,"about_ca_topic_score_gemma":0.00002654537,"domain_scores_codex":[0.9981932,0.0001465213,0.0002986112,0.0006422599,0.0001699063,0.0005494986],"domain_scores_gemma":[0.9991804,0.00002374186,0.0001145644,0.0004148416,0.00008372634,0.0001827202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005271817,0.0002698744,0.005369329,0.00002333467,0.00004263436,0.00006825111,0.00003293987,0.00001759373,0.979507,0.00005025627,0.01274964,0.001816403],"study_design_scores_gemma":[0.001733804,0.0004421473,0.001455275,0.0000261509,0.00001387796,0.00005844643,0.0000873305,0.00009755631,0.7695246,0.00006025713,0.2263214,0.000179095],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924344,0.002282976,0.0001740045,0.0006618192,0.0001638602,0.0006789681,0.0001961414,0.00002742664,0.00338041],"genre_scores_gemma":[0.9961066,0.0002283233,0.0002054294,0.002081285,0.0001132124,0.0003002845,0.000392199,0.00005298287,0.0005196529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2135718,"threshold_uncertainty_score":0.9999886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00548635022812432,"score_gpt":0.2403664016578831,"score_spread":0.2348800514297588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}