{"id":"W2936098930","doi":"10.1001/jamapediatrics.2019.0797","title":"Ethical Review and Methodologic Innovation in Phase 1 Cancer Trials—Reply","year":2019,"lang":"en","type":"letter","venue":"JAMA Pediatrics","topic":"Childhood Cancer Survivors' Quality of Life","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Medicine; Otorhinolaryngology; Family medicine; Neurology; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.01971982,0.0005277442,0.003299185,0.0008486224,0.00004013161,0.00005939225,0.0002435193,0.002796958,0.00042965],"category_scores_gemma":[0.04757636,0.0004502212,0.0002571259,0.001970418,0.000090136,0.0001064527,0.0001394991,0.008887216,0.000047267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003128907,"about_ca_system_score_gemma":0.001179232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005359151,"about_ca_topic_score_gemma":0.00002911592,"domain_scores_codex":[0.9915614,0.003155232,0.002756495,0.0009428724,0.001071828,0.0005121721],"domain_scores_gemma":[0.9890547,0.007763976,0.001735223,0.0008173644,0.0005430964,0.00008563746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001415516,0.00006682832,0.001046547,0.01895346,0.00007191265,0.000119849,0.0002004831,2.974727e-7,0.000006916383,0.00004141219,0.9706161,0.008734615],"study_design_scores_gemma":[0.005376405,0.0003023098,0.0006583206,0.001802451,0.001975007,0.00004752785,0.00001703625,0.000005417118,0.000008190172,0.0004175215,0.9889002,0.0004895969],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001789953,0.09545725,0.0002519714,0.898149,0.001389127,0.002241163,0.0002941518,0.00008466219,0.0003427235],"genre_scores_gemma":[0.00003538253,0.09947866,0.002186363,0.8795965,0.01667995,0.0001694722,0.0008266196,0.00007857579,0.0009485154],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02785654,"threshold_uncertainty_score":0.999795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2197102025005575,"score_gpt":0.4753245871543533,"score_spread":0.2556143846537958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}