{"id":"W2936098930","doi":"10.1001/jamapediatrics.2019.0797","title":"Ethical Review and Methodologic Innovation in Phase 1 Cancer Trials—Reply","year":2019,"lang":"en","type":"letter","venue":"JAMA Pediatrics","topic":"Childhood Cancer Survivors' Quality of Life","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Medicine; Otorhinolaryngology; Family medicine; Neurology; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.08330017,0.001277015,0.001981431,0.001767865,0.004093138,0.006017244,0.005233211,0.0591791,0.007208911],"category_scores_gemma":[0.3158217,0.001577524,0.00279454,0.002406781,0.01131615,0.009262171,0.003408243,0.06286024,0.006285948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.007406368,"about_ca_system_score_gemma":0.01409901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006024613,"about_ca_topic_score_gemma":0.007082114,"domain_scores_codex":[0.9408046,0.02895785,0.01223209,0.004668107,0.01094872,0.002388772],"domain_scores_gemma":[0.667384,0.2728978,0.01123847,0.007439776,0.03335138,0.007688592],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006944986,0.00002371654,0.0007728126,0.0001780261,0.00004633154,0.0003861256,0.0003572509,0.00008898009,0.00009213599,0.002999762,0.9850638,0.009921659],"study_design_scores_gemma":[0.0004979933,0.0001966582,0.00314496,0.001621931,0.0001595213,0.002674045,0.001397889,0.001233083,0.0006597626,0.02303776,0.9650788,0.0002976121],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.000151847,0.0005225557,0.0003192858,0.9882068,0.01025129,0.00003232481,0.00006399494,0.00004871196,0.0004031488],"genre_scores_gemma":[0.001402294,0.0003681996,0.0007910766,0.9810511,0.01561715,0.0001219697,0.00002197173,0.00002380728,0.0006024447],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.9166998,"threshold_uncertainty_score":0.4405387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2197102025005575,"score_gpt":0.4753245871543533,"score_spread":0.2556143846537958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}