{"id":"W2936145201","doi":"10.1200/po.18.00327","title":"Genomic Characterization of Prostatic Ductal Adenocarcinoma Identifies a High Prevalence of DNA Repair Gene Mutations","year":2019,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Prostate Cancer Diagnosis and Treatment","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Cancer Institute","keywords":"DNA repair; Mutation; Prostate cancer; Cancer research; Wnt signaling pathway; Cancer; Gene; Biology; Medicine; Adenocarcinoma; DNA sequencing; Germline mutation; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000343914,0.0001886386,0.0002283224,0.001774671,0.000369495,0.0005244219,0.000282495,0.0002752298,0.0015105],"category_scores_gemma":[0.001147278,0.0001596831,0.0001331304,0.0009954202,0.0003239728,0.0002072616,0.0003324626,0.0001989666,0.0002281081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002054903,"about_ca_system_score_gemma":0.0002091122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007958501,"about_ca_topic_score_gemma":0.001842473,"domain_scores_codex":[0.9995059,0.00006922977,0.00005825091,0.0001460912,0.0001690946,0.00005145956],"domain_scores_gemma":[0.9991859,0.0002260689,0.0002659446,0.00008338514,0.0001312622,0.0001074613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00008144078,0.00002408703,0.9578689,0.00005119168,0.00004723911,0.001488083,0.0001613666,0.0001249387,0.03108056,0.00004041497,0.00009643379,0.008935277],"study_design_scores_gemma":[0.000005803256,0.0001215897,0.9722163,0.00001221489,0.00004402,0.01713892,0.0003459667,0.0003731749,0.008822446,0.0000526545,0.0008615769,0.000005325478],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986613,0.0004292454,0.0003820584,0.00001877198,0.000001764456,0.000006880111,0.0001321778,0.00001620076,0.0003515671],"genre_scores_gemma":[0.999172,0.0001395243,0.0004264338,0.00001554428,0.000005344982,0.000004497669,0.0001651449,0.000004075351,0.00006744917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001774671,"threshold_uncertainty_score":0.005053103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01609385672609186,"score_gpt":0.2903022285146727,"score_spread":0.2742083717885808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}