{"id":"W2936145201","doi":"10.1200/po.18.00327","title":"Genomic Characterization of Prostatic Ductal Adenocarcinoma Identifies a High Prevalence of DNA Repair Gene Mutations","year":2019,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Prostate Cancer Diagnosis and Treatment","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Cancer Institute","keywords":"DNA repair; Mutation; Prostate cancer; Cancer research; Wnt signaling pathway; Cancer; Gene; Biology; Medicine; Adenocarcinoma; DNA sequencing; Germline mutation; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002051324,0.0001294742,0.0004736508,0.000167367,0.00002789377,0.000004626224,0.00008538734,0.0001055533,0.0005047343],"category_scores_gemma":[0.00009578582,0.0001096785,0.0001222253,0.0001666216,0.00009811653,0.0001101726,0.00007078463,0.0000780517,0.00006360906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000235089,"about_ca_system_score_gemma":0.0003179826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003005228,"about_ca_topic_score_gemma":0.000003942554,"domain_scores_codex":[0.998584,0.00009109324,0.0006051332,0.0003308997,0.0002276999,0.0001611432],"domain_scores_gemma":[0.998653,0.0002042383,0.0004267668,0.0003865496,0.0002612486,0.00006822205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004610145,0.0006233598,0.3452033,0.0006225812,0.0001343484,0.00003127363,0.001085051,0.00001338752,0.648151,0.0001308924,0.00008775719,0.003456101],"study_design_scores_gemma":[0.001727481,0.002299321,0.8356159,0.0001929889,0.0002286019,0.00005722983,0.0000641708,0.0001230742,0.1591789,0.0002250537,0.0002141905,0.00007304503],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967485,0.0005918773,0.00008123117,0.0003383393,0.0004407321,0.001481368,0.0001613487,0.00003419763,0.0001223703],"genre_scores_gemma":[0.9963872,0.0007408282,0.001465988,0.00006789794,0.00004793528,0.0001529924,0.0001964011,0.00001912399,0.0009215827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4904127,"threshold_uncertainty_score":0.5526487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01609385672609186,"score_gpt":0.2903022285146727,"score_spread":0.2742083717885808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}