{"id":"W2936179117","doi":"10.1016/j.exphem.2019.03.004","title":"ETV6-RUNX1 interacts with a region in SPIB intron 1 to regulate gene expression in pre-B-cell acute lymphoblastic leukemia","year":2019,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children’s Health Research Institute; Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research","keywords":"Intron; Gene; RUNX1; Biology; Lymphoblastic Leukemia; ETV6; Leukemia; Genetics; Gene expression; Cancer research; Molecular biology; Cell biology; Transcription factor; Chromosomal translocation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002186094,0.0002056989,0.0002453358,0.0002201506,0.0003016508,0.0003932159,0.0004110231,0.0003461667,0.002315073],"category_scores_gemma":[0.0001330072,0.0002060227,0.0003419942,0.0001573399,0.0003434714,0.0001653881,0.0003417346,0.0009106373,0.0008029986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005383336,"about_ca_system_score_gemma":0.0002357033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008127004,"about_ca_topic_score_gemma":0.001986209,"domain_scores_codex":[0.9997799,0.0000337126,0.00001437514,0.00004912242,0.00007974428,0.00004317928],"domain_scores_gemma":[0.999927,0.00001530183,0.00002106292,0.000008368485,0.000004867154,0.00002330555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000130249,0.00002812019,0.0003782461,0.00002765325,0.000005817685,0.00007448306,0.00002055589,0.0002280199,0.9973478,0.0004516738,0.0001097234,0.0011976],"study_design_scores_gemma":[0.00005988872,0.0000943653,0.006475824,0.00001287313,0.00001762447,0.000285373,0.00006817912,0.00526959,0.9790456,0.0002144013,0.008446321,0.000009974869],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895692,0.00109301,0.005837011,0.0002069571,0.00007038852,0.00002557987,0.000492621,0.0001950811,0.00251025],"genre_scores_gemma":[0.9936677,0.0002342965,0.002203672,0.00009602726,0.000004871307,0.00001699841,0.0005136306,0.00006441237,0.003198402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002315073,"threshold_uncertainty_score":0.00774467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003545811376179333,"score_gpt":0.2676887937742777,"score_spread":0.2641429823980984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}