{"id":"W2936379593","doi":"10.1016/j.joca.2019.02.011","title":"Safe cell and gene therapy combination: are we there yet in arthritis?","year":2019,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute","funders":"","keywords":"Arthritis; Induced pluripotent stem cell; Medicine; Genetic enhancement; Disease; Computational biology; Bioinformatics; Cell; Cancer research; Gene; Immunology; Biology; Internal medicine; Genetics; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01230607,0.001062559,0.005053104,0.0009642623,0.0009413778,0.006273349,0.002103972,0.005608018,0.02678561],"category_scores_gemma":[0.007923021,0.0006368497,0.00183142,0.0009241359,0.003146752,0.01096308,0.001607628,0.007587108,0.004919428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001269777,"about_ca_system_score_gemma":0.004726902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001004298,"about_ca_topic_score_gemma":0.00469543,"domain_scores_codex":[0.9965766,0.001364533,0.0003411587,0.0003252625,0.000880717,0.00051175],"domain_scores_gemma":[0.9912407,0.005175,0.001111465,0.0004418358,0.001211374,0.0008195828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.007214097,0.00241978,0.005751646,0.005449746,0.001432885,0.0008007763,0.0003992985,0.001273116,0.01699298,0.02614755,0.07608921,0.856029],"study_design_scores_gemma":[0.004378122,0.01900927,0.01085954,0.01036709,0.004329571,0.004562512,0.003742765,0.003342174,0.02210262,0.0768989,0.8398986,0.0005088428],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"commentary","genre_scores_codex":[0.02808612,0.75077,0.01650775,0.1824572,0.007472793,0.0002870553,0.0005868629,0.0004541218,0.01337813],"genre_scores_gemma":[0.286557,0.5170769,0.04040818,0.1071218,0.01848742,0.001213882,0.001156093,0.0003108601,0.02766784],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.02678561,"threshold_uncertainty_score":0.08960682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01507664927577347,"score_gpt":0.2535215225541983,"score_spread":0.2384448732784248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}