{"id":"W2936481262","doi":"10.1016/j.cell.2019.03.013","title":"Human Pluripotency Is Initiated and Preserved by a Unique Subset of Founder Cells","year":2019,"lang":"en","type":"article","venue":"Cell","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Japan Society for the Promotion of Science; Canadian Institutes of Health Research; Cancer Research Institute","keywords":"Biology; Founder effect; Genetics; Evolutionary biology; Cell biology; Computational biology; Gene; Haplotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000263819,0.0003572984,0.0005964303,0.0007474411,0.000300955,0.0008321825,0.0003467873,0.0003323358,0.002502568],"category_scores_gemma":[0.0004349712,0.0001708495,0.0003105439,0.0004550373,0.0001828212,0.0004488394,0.0005479277,0.0004315852,0.001200353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001346729,"about_ca_system_score_gemma":0.0001775514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001723982,"about_ca_topic_score_gemma":0.0002681288,"domain_scores_codex":[0.9997794,0.00002281582,0.00003384511,0.00006479274,0.00005217242,0.00004695712],"domain_scores_gemma":[0.9996046,0.00007633916,0.00008425167,0.0001126523,0.00005232512,0.00006982624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001593255,0.00002306651,0.003606473,0.00002025651,0.000013368,0.0003441392,0.0000691263,0.00003659315,0.9891788,0.0004701906,0.0001370176,0.005941819],"study_design_scores_gemma":[0.00005344441,0.0008013814,0.07250791,0.00001453446,0.0001555246,0.01789148,0.0002313686,0.0007021622,0.8804683,0.0009090122,0.02623122,0.00003365159],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879358,0.001704212,0.005180914,0.0001216292,0.00002941564,0.00004819361,0.001459759,0.0002237609,0.003296383],"genre_scores_gemma":[0.9865447,0.001080593,0.003154326,0.0001030683,0.00008070376,0.00005752806,0.003228996,0.00009677702,0.005653245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002502568,"threshold_uncertainty_score":0.00837189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01808633649837646,"score_gpt":0.2652028026416509,"score_spread":0.2471164661432744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}