{"id":"W2936481262","doi":"10.1016/j.cell.2019.03.013","title":"Human Pluripotency Is Initiated and Preserved by a Unique Subset of Founder Cells","year":2019,"lang":"en","type":"article","venue":"Cell","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Japan Society for the Promotion of Science; Canadian Institutes of Health Research; Cancer Research Institute","keywords":"Biology; Founder effect; Genetics; Evolutionary biology; Cell biology; Computational biology; Gene; Haplotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001614387,0.0001381969,0.0001622283,0.0000423083,0.000037431,0.00001771486,0.0002371779,0.0001759623,0.000233372],"category_scores_gemma":[0.000007117892,0.0001346704,0.0000571278,0.00007710916,0.00008503007,0.00000508619,0.0002080385,0.0001060791,0.00004381388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008427045,"about_ca_system_score_gemma":0.00004788869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000851213,"about_ca_topic_score_gemma":0.00001459897,"domain_scores_codex":[0.9989403,0.00008698487,0.0001984788,0.0003495049,0.000164213,0.0002605525],"domain_scores_gemma":[0.9992929,0.00001165143,0.00007884328,0.0004232463,0.00009829976,0.00009513116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002546598,0.00008437686,0.003002069,0.0001443938,0.00002431266,0.000001931608,0.00003273716,0.000003513902,0.9794204,0.000005228161,0.01724065,0.00001495761],"study_design_scores_gemma":[0.0007895305,0.0002943634,0.001281243,0.0000132678,0.000008262968,0.000001123659,0.00003898978,0.0000478446,0.9808278,0.00006816714,0.01647602,0.0001534081],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873243,0.0008083539,0.00004111196,0.00005496459,0.00004074428,0.0003252752,0.00007198417,0.000007627134,0.01132566],"genre_scores_gemma":[0.9826536,0.0002369813,0.00008049347,0.0001270701,0.00001994732,0.000008459617,0.0001649201,0.00002545714,0.01668313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005357469,"threshold_uncertainty_score":0.5491701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01808633649837646,"score_gpt":0.2652028026416509,"score_spread":0.2471164661432744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}