{"id":"W2936549068","doi":"10.3390/molecules24081511","title":"Novel C-2 Symmetric Molecules as α-Glucosidase and α-Amylase Inhibitors: Design, Synthesis, Kinetic Evaluation, Molecular Docking and Pharmacokinetics","year":2019,"lang":"en","type":"article","venue":"Molecules","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Population and Public Health; King Saud University","keywords":"Docking (animal); Chemistry; Pharmacokinetics; Combinatorial chemistry; Stereochemistry; Molecule; Computational chemistry; Pharmacology; Organic chemistry; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004357236,0.0004991625,0.000435655,0.0002037886,0.0001287422,0.0002164204,0.0002520174,0.0002418786,0.0006424395],"category_scores_gemma":[0.0009838917,0.0005175776,0.0001167392,0.0003809673,0.0001563606,0.00012269,0.0002003866,0.0002647351,0.00003929763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009154087,"about_ca_system_score_gemma":0.00009889312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006220717,"about_ca_topic_score_gemma":0.000001133721,"domain_scores_codex":[0.9974146,0.0001004587,0.0004809291,0.0008510317,0.0006679088,0.0004851063],"domain_scores_gemma":[0.99814,0.0006260228,0.0002028172,0.0005425769,0.0002024453,0.0002861643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000607238,0.0001256834,0.0002048049,0.0003208587,0.0001154119,0.00006102618,0.0001021797,0.001258645,0.9884713,0.0001685523,0.00005788959,0.009052931],"study_design_scores_gemma":[0.001085073,0.00003025307,0.00008913262,0.000269521,0.0003834147,0.0001380738,0.0001685086,0.03062877,0.9656302,0.0003670114,0.0006141796,0.0005958216],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848225,0.005338492,0.001249208,0.000201944,0.0000721796,0.0003312863,0.00003905161,0.0001078756,0.007837432],"genre_scores_gemma":[0.9972976,0.0003169819,0.001743871,0.0001822946,0.0001018883,0.0001301655,0.00002949158,0.00008569078,0.000112011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02937012,"threshold_uncertainty_score":0.9997276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0161128915465723,"score_gpt":0.2485367859385755,"score_spread":0.2324238943920032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}