{"id":"W2936630487","doi":"10.1101/607218","title":"Mesoscale Modeling of a Nucleosome-Binding Antibody (PL2-6): Mono- vs. Bivalent Chromatin Complexes","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; National Institute of General Medical Sciences; University of New England; York University","keywords":"Chromatin; Linker DNA; Biophysics; Bivalent chromatin; Histone; Nucleosome; Linker; Bivalent (engine); Chemistry; Cell biology; Molecular biology; Biology; DNA; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001184333,0.0003409193,0.0004024538,0.0002614365,0.0004279493,0.0007741289,0.0008059999,0.0009751981,0.002508485],"category_scores_gemma":[0.0002767085,0.0003501617,0.0004430121,0.0002135808,0.0005404506,0.0004643484,0.0004696648,0.0004997368,0.0002588577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001131693,"about_ca_system_score_gemma":0.0006009039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01122117,"about_ca_topic_score_gemma":0.005950841,"domain_scores_codex":[0.9999313,0.00001122207,0.000002780767,0.00001602851,0.00001743922,0.00002127495],"domain_scores_gemma":[0.9998736,0.0000416977,0.00002130025,0.00001509934,0.00001678062,0.00003141079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00004078416,0.00004625683,0.001427722,0.00002406506,0.00002492881,0.0001403893,0.00004182876,0.9811157,0.01411392,0.002289266,0.0001347023,0.0006005283],"study_design_scores_gemma":[0.000007078922,0.000008422267,0.0005142826,0.000001649059,0.000003187642,0.000006898795,0.00001225947,0.9985706,0.0004283978,0.0003341952,0.0001092571,0.000003885682],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9576086,0.0001664926,0.03457198,0.0003480756,0.00002784483,0.00003648466,0.0003199537,0.0001977255,0.006722835],"genre_scores_gemma":[0.9920655,0.0001085356,0.006047974,0.00006147813,0.000007003785,0.00005611299,0.0001596983,0.00005792396,0.001435814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01122117,"threshold_uncertainty_score":0.02231169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01059810982795331,"score_gpt":0.2265195654249965,"score_spread":0.2159214555970432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}