{"id":"W2936647836","doi":"10.3389/fendo.2019.00219","title":"Orexin-A Prevents Lipopolysaccharide-Induced Neuroinflammation at the Level of the Intestinal Barrier","year":2019,"lang":"en","type":"article","venue":"Frontiers in Endocrinology","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Neuroinflammation; Occludin; Tight junction; Orexin-A; Lipopolysaccharide; Intestinal permeability; Blood–brain barrier; Cell biology; Gut–brain axis; Myenteric plexus; Biology; Microglia; Chemistry; Inflammation; Neuropeptide; Immunology; Internal medicine; Central nervous system; Endocrinology; Orexin; Receptor; Medicine; Immunohistochemistry; Gut flora","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001239343,0.0002680682,0.00038168,0.0002229055,0.0001817258,0.000165297,0.0001877603,0.0003033009,0.0009032377],"category_scores_gemma":[0.000100577,0.000118361,0.0002447233,0.0000896436,0.0003134485,0.0002327028,0.0001916382,0.0007085669,0.0001510661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001592655,"about_ca_system_score_gemma":0.0003774027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005454334,"about_ca_topic_score_gemma":0.001091619,"domain_scores_codex":[0.9999404,0.00001022677,0.000006785756,0.00001059133,0.000009251362,0.00002271374],"domain_scores_gemma":[0.9999179,0.000007424775,0.00002226013,0.000009073094,0.000007975852,0.00003540629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003009079,0.0003772398,0.0001939201,0.0001592516,0.00001704859,0.00008277033,0.00003179758,0.00007627043,0.9907059,0.0001594009,0.0000675999,0.00511972],"study_design_scores_gemma":[0.0005072703,0.01191692,0.01557115,0.00006622661,0.00006842114,0.0002805737,0.0001699714,0.0009751542,0.9665766,0.0004358469,0.003417438,0.00001445118],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965552,0.001527708,0.0008696294,0.0001108904,0.00005626998,0.00003781133,0.0001119897,0.00004862489,0.0006817785],"genre_scores_gemma":[0.9929122,0.002173576,0.001996936,0.0000899292,0.00002694975,0.00007102346,0.0001884829,0.00001673674,0.002524079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009032377,"threshold_uncertainty_score":0.003021657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07019908155796126,"score_gpt":0.2990958485627801,"score_spread":0.2288967670048188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}